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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-7-10
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pubmed:abstractText |
Activation of cells from the innate immune system has an important role in host resistance to early infection with the intracellular protozoan parasite, Trypanosoma cruzi. Here we review the studies that have identified and structurally characterized the glycosylphosphatidylinositol (GPI) anchors, as parasite molecules responsible for the activation of cells from the macrophage lineage. We also cover the studies that have identified the receptor, signaling pathways as well as the array of genes expressed in macrophages that are activated by these glycoconjugates. We discuss the possible implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1286-4579
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1015-25
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12106796-Animals,
pubmed-meshheading:12106796-Carbohydrate Sequence,
pubmed-meshheading:12106796-Cytokines,
pubmed-meshheading:12106796-Drosophila Proteins,
pubmed-meshheading:12106796-Gene Expression Regulation,
pubmed-meshheading:12106796-Glycoproteins,
pubmed-meshheading:12106796-Glycosylphosphatidylinositols,
pubmed-meshheading:12106796-Humans,
pubmed-meshheading:12106796-Immunity, Innate,
pubmed-meshheading:12106796-Macrophages,
pubmed-meshheading:12106796-Membrane Glycoproteins,
pubmed-meshheading:12106796-Molecular Sequence Data,
pubmed-meshheading:12106796-Receptors, Cell Surface,
pubmed-meshheading:12106796-Signal Transduction,
pubmed-meshheading:12106796-Structure-Activity Relationship,
pubmed-meshheading:12106796-Toll-Like Receptors,
pubmed-meshheading:12106796-Trypanosoma cruzi
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pubmed:year |
2002
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pubmed:articleTitle |
Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes.
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pubmed:affiliation |
Laboratory of Immunopathology, CPqRR-FIOCRUZ, Av. Augusto de Lima 1715, MG, Belo Horizonte, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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