| pubmed-article:12104051 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12104051 | lifeskim:mentions | umls-concept:C0018873 | lld:lifeskim |
| pubmed-article:12104051 | lifeskim:mentions | umls-concept:C0012920 | lld:lifeskim |
| pubmed-article:12104051 | lifeskim:mentions | umls-concept:C1148798 | lld:lifeskim |
| pubmed-article:12104051 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12104051 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12104051 | lifeskim:mentions | umls-concept:C1517317 | lld:lifeskim |
| pubmed-article:12104051 | lifeskim:mentions | umls-concept:C0205087 | lld:lifeskim |
| pubmed-article:12104051 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12104051 | pubmed:dateCreated | 2002-7-9 | lld:pubmed |
| pubmed-article:12104051 | pubmed:abstractText | DNA topoisomerase IIalpha (Topo IIalpha) is regulated in late S phase-dependent manner. To identify late S phase-dependent cis-acting elements of Topo IIalpha gene, we have investigated the synchronized HeLa cells with chloramphenicol acetyltransferase and DNase I footprinting assays. The level of Topo IIalpha mRNA increased after release from aphidicolin block and reached a maximum in 8h (late S phase) in HeLa cells, and Topo II unknotting activity was also in parallel with the level of Topo IIalpha mRNA. The late S phase-regulatory element was found to be located in the region containing ATF-binding element between -290 and -90bp and the region was required for a maximal stimulation during late S phase. DNase I footprinting assay showed that ATF-binding element and novel cis-acting element (Topo IIalpha-specific sequence) were the principal protein-binding sites and the proteins interacting with these elements were induced during late S phase. One DNA-protein complex was formed by DNA mobility shift assay when ATF-binding site was incubated with nuclear extract prepared from late S phase cells, but no protein bound in non-S phase cells. Taken together, these results suggest that ATF may be essential transacting factor for maximal expression of Topo IIalpha gene during late S phase in HeLa cells. | lld:pubmed |
| pubmed-article:12104051 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12104051 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12104051 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12104051 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12104051 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:JoeL KLK | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:YoonWan-HeeWH | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:AhnJong-Woong... | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:SonMee-YoungM... | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:KimTae-JeongT... | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:KweonKwang-In... | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:ParkJong-IlJI | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:ParkChungC | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:LeeYoung-Chul... | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:NoZaesungZ | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:ParkSeung-Kie... | lld:pubmed |
| pubmed-article:12104051 | pubmed:author | pubmed-author:HwangByung-Do... | lld:pubmed |
| pubmed-article:12104051 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12104051 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:12104051 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:12104051 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12104051 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12104051 | pubmed:pagination | 81-8 | lld:pubmed |
| pubmed-article:12104051 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12104051 | pubmed:meshHeading | pubmed-meshheading:12104051... | lld:pubmed |
| pubmed-article:12104051 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12104051 | pubmed:articleTitle | ATF is important to late S phase-dependent regulation of DNA topoisomerase IIalpha gene expression in HeLa cells. | lld:pubmed |
| pubmed-article:12104051 | pubmed:affiliation | Department of Biochemistry, Chungnam National University, Moonhwa-dong, Jungu, Daejeon 301-747, South Korea. | lld:pubmed |
| pubmed-article:12104051 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12104051 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
