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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-7-4
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pubmed:abstractText |
It has been proposed that expression of the chemokine receptor CCR7 represents a defining factor for nonpolarized central (CCR7(+)) and polarized effector memory (CCR7(-)) T cells. In this study, we have tested this hypothesis using in vivo-activated T cells from P14 and SMARTA TCR-transgenic (tg) mice specific for MHC class I- and II-restricted epitopes of the lymphocytic choriomeningitis virus (LCMV) glycoprotein. CCR7 cell surface expression on TCR-tg cells was monitored with a CC chemokine ligand 19-Ig fusion protein. CC chemokine ligand 19-Ig staining separated TCR-tg cells activated by LCMV infection into CCR7(-) and CCR7(+) effector/memory T cell populations. Nonetheless, both T cell populations isolated from spleen and liver produced identical amounts of IFN-gamma after short-term Ag stimulation. Furthermore, CCR7(+) and CCR7(-) CD8 TCR-tg cells from LCMV-infected mice exhibited similar lytic activity against LCMV peptide-coated target cells. These results question the proposed concept of differential effector cell function of CCR7(+) and CCR7(-) memory T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Ccr7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein peptide 33-41...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
638-41
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12097363-Amino Acid Sequence,
pubmed-meshheading:12097363-Animals,
pubmed-meshheading:12097363-Antigens, Viral,
pubmed-meshheading:12097363-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12097363-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12097363-Cell Membrane,
pubmed-meshheading:12097363-Cytokines,
pubmed-meshheading:12097363-Cytotoxicity, Immunologic,
pubmed-meshheading:12097363-Epitopes, T-Lymphocyte,
pubmed-meshheading:12097363-Glycoproteins,
pubmed-meshheading:12097363-Immunologic Memory,
pubmed-meshheading:12097363-Kinetics,
pubmed-meshheading:12097363-Lymphocyte Activation,
pubmed-meshheading:12097363-Lymphocytic choriomeningitis virus,
pubmed-meshheading:12097363-Mice,
pubmed-meshheading:12097363-Mice, Inbred C57BL,
pubmed-meshheading:12097363-Mice, Knockout,
pubmed-meshheading:12097363-Mice, Transgenic,
pubmed-meshheading:12097363-Molecular Sequence Data,
pubmed-meshheading:12097363-Peptide Fragments,
pubmed-meshheading:12097363-Receptors, CCR7,
pubmed-meshheading:12097363-Receptors, Chemokine,
pubmed-meshheading:12097363-T-Lymphocyte Subsets,
pubmed-meshheading:12097363-Viral Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
Cutting edge: CCR7+ and CCR7- memory T cells do not differ in immediate effector cell function.
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pubmed:affiliation |
Department of Immunology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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