Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2002-7-10
pubmed:abstractText
Erk5 is a mitogen-activated protein kinase, the biological role of which is largely undefined. Therefore, we deleted the erk5 gene in mice to assess its function in vivo. Inactivation of the erk5 gene resulted in defective blood-vessel and cardiac development leading to embryonic lethality around embryonic days 9.5-10.5. Cardiac development was retarded largely, and the heart failed to undergo normal looping. Endothelial cells that line the developing myocardium of erk5-/- embryos displayed a disorganized, rounded morphology. Vasculogenesis occurred, but extraembryonic and embryonic blood vessels were disorganized and failed to mature. Furthermore, the investment of embryonic blood vessels with smooth muscle cells was attenuated. Together, these data define an essential role for Erk5 in cardiovascular development. Moreover, the inability of Erk5-deficient mice to form a complex vasculature suggests that Erk5 may play an important role in controlling angiogenesis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10209122, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10347227, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10395786, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10473620, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10593883, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10700190, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10728377, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10742145, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10943842, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10949032, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-10973481, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-11001064, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-11046135, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-11067866, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-11139578, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-11242034, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-11397016, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-11520859, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-11857442, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-7596437, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-7759517, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-8200973, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-8649370, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-8663194, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-8980224, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-9069290, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-9162005, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-9229772, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-9384584, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-9753748, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-9778514, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-9790194, http://linkedlifedata.com/resource/pubmed/commentcorrection/12093914-9867822
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9248-53
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects.
pubmed:affiliation
Vertex Pharmaceuticals, Department of Biology, 130 Waverly Street, Cambridge, MA 02139, USA.
pubmed:publicationType
Journal Article