Source:http://linkedlifedata.com/resource/pubmed/id/12089670
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2002-6-28
|
| pubmed:abstractText |
Organ transplant recipients have a higher risk of Kaposi sarcoma (KS). A quantitative real-time polymerase chain reaction assay was developed to evaluate KS-associated herpesvirus (KSHV) as a prognostic tool in transplant recipients with KS. Forty-three patients who developed KS after transplantation were included in a cross-sectional study to correlate virus load with transplantation or KS parameters. Seventeen patients (40%) had KSHV viremia (>100 copies/microg of DNA; median, 6067 copies/microg of DNA). Factors associated with these levels of viremia by univariate analysis were progression of KS (P=.00002), time from KS diagnosis (P=.0007), actual stage of KS (P=.006), initial stage of KS (P=.22), graft loss (P=.013), and time from transplantation (P=.0246). Disease progression remained associated with KSHV viremia in a multivariate analysis (P=.01). Thus, quantification of KSHV load in peripheral blood mononuclear cells could represent a useful tool for monitoring transplant recipients with KS.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-1899
|
| pubmed:author |
pubmed-author:AgbalikaFélixF,
pubmed-author:AntoineCorinneC,
pubmed-author:CalmusYvonY,
pubmed-author:CalvoFabienF,
pubmed-author:ChevretSylvieS,
pubmed-author:DalacSophieS,
pubmed-author:EuvrardSylvieS,
pubmed-author:FargeDominiqueD,
pubmed-author:FrancèsCamilleC,
pubmed-author:HiesseChristianC,
pubmed-author:HuraultMylèneM,
pubmed-author:LangPhilippeP,
pubmed-author:LebbéCélesteC,
pubmed-author:LegendreChristopheC,
pubmed-author:MorelPatriceP,
pubmed-author:PelletClaireC,
pubmed-author:PeraldiMarie-NoëlleMN,
pubmed-author:SamuelDidierD
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
186
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
110-3
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12089670-Cohort Studies,
pubmed-meshheading:12089670-Cross-Sectional Studies,
pubmed-meshheading:12089670-DNA, Viral,
pubmed-meshheading:12089670-Herpesvirus 8, Human,
pubmed-meshheading:12089670-Humans,
pubmed-meshheading:12089670-Kidney Transplantation,
pubmed-meshheading:12089670-Monocytes,
pubmed-meshheading:12089670-Polymerase Chain Reaction,
pubmed-meshheading:12089670-Postoperative Complications,
pubmed-meshheading:12089670-Prognosis,
pubmed-meshheading:12089670-Sarcoma, Kaposi,
pubmed-meshheading:12089670-Viral Load,
pubmed-meshheading:12089670-Viremia
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Prognostic value of quantitative Kaposi sarcoma--associated herpesvirus load in posttransplantation Kaposi sarcoma.
|
| pubmed:affiliation |
Laboratory of Pharmacology, Hôpital Saint-Louis, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|