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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-6-27
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pubmed:abstractText |
Inactivation of the von Hippel-Lindau tumor suppressor gene is linked to the development of hereditary (VHL Disease-associated) and sporadic clear cell carcinoma of the kidney. The VHL gene product, pVHL, targets the heterodimeric transcription factor HIF for polyubiquitination, and restoration of pVHL function in VHL(-/-) renal carcinoma cells suppresses their ability to form tumors in nude mice. Here we show that tumor suppression by pVHL can be overridden by a HIF variant that escapes pVHL control. These studies prove that HIF is a critical downstream target of pVHL and establish that activation of HIF target genes can promote tumorigenesis in vivo.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/SLC2A1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/VHL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Von Hippel-Lindau Tumor Suppressor...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1535-6108
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
237-46
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12086860-Animals,
pubmed-meshheading:12086860-Blotting, Western,
pubmed-meshheading:12086860-Carcinoma, Renal Cell,
pubmed-meshheading:12086860-Cycloheximide,
pubmed-meshheading:12086860-Down-Regulation,
pubmed-meshheading:12086860-Genes, Tumor Suppressor,
pubmed-meshheading:12086860-Glucose Transporter Type 1,
pubmed-meshheading:12086860-Humans,
pubmed-meshheading:12086860-Immunoenzyme Techniques,
pubmed-meshheading:12086860-Kidney Neoplasms,
pubmed-meshheading:12086860-Ligases,
pubmed-meshheading:12086860-Mice,
pubmed-meshheading:12086860-Mice, Nude,
pubmed-meshheading:12086860-Monosaccharide Transport Proteins,
pubmed-meshheading:12086860-Mutation,
pubmed-meshheading:12086860-Plasmids,
pubmed-meshheading:12086860-Protein Synthesis Inhibitors,
pubmed-meshheading:12086860-Retroviridae,
pubmed-meshheading:12086860-Transcription Factors,
pubmed-meshheading:12086860-Transfection,
pubmed-meshheading:12086860-Tumor Cells, Cultured,
pubmed-meshheading:12086860-Tumor Suppressor Proteins,
pubmed-meshheading:12086860-Ubiquitin-Protein Ligases,
pubmed-meshheading:12086860-Von Hippel-Lindau Tumor Suppressor Protein
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pubmed:year |
2002
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pubmed:articleTitle |
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
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pubmed:affiliation |
Department of Adult Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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