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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
29
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pubmed:dateCreated |
2002-6-26
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pubmed:abstractText |
Overexpression of the melanoma differentiation associated gene-7 (mda-7) in vitro results in suppression of lung cancer cell proliferation. However, the ability of MDA-7 to suppress lung cancer in vivo has not been previously demonstrated. In this study, we investigated the possibility of inducing overexpression of the mda-7 gene in human non-small cell lung carcinoma cells in vivo and its effects on tumor growth. Adenovirus-mediated overexpression of MDA-7 in p53-wild-type A549 and p53-null H1299 subcutaneous tumors resulted in significant tumor growth inhibition through induction of apoptosis. In addition, decreased CD31/PECAM expression and upregulation of APO2/TRAIL were observed in tumors expressing MDA-7. In vivo studies correlated well with in vitro inhibition of lung tumor cell proliferation and endothelial cell differentiation mediated by Ad-mda7. These data demonstrate that Ad-mda7 functions as a multi-modality anti-cancer agent, possessing both, pro-apoptotic and anti-angiogenic properties. We demonstrate for the first time the potential therapeutic effects of Ad-mda7 in human lung cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, TNF-Related...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF10A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf10 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-24
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0950-9232
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pubmed:author |
pubmed-author:BranchCynthia DCD,
pubmed-author:ChadaSunilS,
pubmed-author:KawabeShinichiroS,
pubmed-author:MeynRaymond ERE,
pubmed-author:MhashilkarAbnerA,
pubmed-author:RameshRajagopalR,
pubmed-author:RothJack AJA,
pubmed-author:SaekiTomoyukiT,
pubmed-author:SiegerKerryK,
pubmed-author:SwansonXinX,
pubmed-author:Zou-YangX HelenaXH,
pubmed-author:ZumsteinLouisL
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4558-66
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12085234-Adenoviridae,
pubmed-meshheading:12085234-Animals,
pubmed-meshheading:12085234-Antigens, CD31,
pubmed-meshheading:12085234-Apoptosis,
pubmed-meshheading:12085234-Apoptosis Regulatory Proteins,
pubmed-meshheading:12085234-Cell Differentiation,
pubmed-meshheading:12085234-Cell Division,
pubmed-meshheading:12085234-Endothelium, Vascular,
pubmed-meshheading:12085234-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12085234-Genes, Tumor Suppressor,
pubmed-meshheading:12085234-Humans,
pubmed-meshheading:12085234-In Situ Nick-End Labeling,
pubmed-meshheading:12085234-Interleukins,
pubmed-meshheading:12085234-Lung Neoplasms,
pubmed-meshheading:12085234-Membrane Glycoproteins,
pubmed-meshheading:12085234-Mice,
pubmed-meshheading:12085234-Neoplasm Transplantation,
pubmed-meshheading:12085234-Receptors, TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:12085234-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:12085234-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:12085234-Time Factors,
pubmed-meshheading:12085234-Transplantation, Heterologous,
pubmed-meshheading:12085234-Tumor Cells, Cultured,
pubmed-meshheading:12085234-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo.
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pubmed:affiliation |
Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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