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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-6-24
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pubmed:abstractText |
Most functional RNA molecules have characteristic secondary structures that are highly conserved in evolution. Here we present a method for computing the consensus structure of a set aligned RNA sequences taking into account both thermodynamic stability and sequence covariation. Comparison with phylogenetic structures of rRNAs shows that a reliability of prediction of more than 80% is achieved for only five related sequences. As an application we show that the Early Noduline mRNA contains significant secondary structure that is supported by sequence covariation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-2836
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2002 Elsevier Science Ltd.
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
319
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1059-66
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12079347-Algorithms,
pubmed-meshheading:12079347-Archaea,
pubmed-meshheading:12079347-Base Sequence,
pubmed-meshheading:12079347-Consensus Sequence,
pubmed-meshheading:12079347-Databases, Nucleic Acid,
pubmed-meshheading:12079347-Escherichia coli,
pubmed-meshheading:12079347-Evolution, Molecular,
pubmed-meshheading:12079347-Molecular Sequence Data,
pubmed-meshheading:12079347-Nucleic Acid Conformation,
pubmed-meshheading:12079347-Phylogeny,
pubmed-meshheading:12079347-Prokaryotic Cells,
pubmed-meshheading:12079347-RNA,
pubmed-meshheading:12079347-RNA, Ribosomal, 16S,
pubmed-meshheading:12079347-RNA, Ribosomal, 23S,
pubmed-meshheading:12079347-RNA Stability,
pubmed-meshheading:12079347-Sequence Alignment,
pubmed-meshheading:12079347-Sequence Homology, Nucleic Acid,
pubmed-meshheading:12079347-Thermodynamics
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pubmed:year |
2002
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pubmed:articleTitle |
Secondary structure prediction for aligned RNA sequences.
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pubmed:affiliation |
Institut für Theoretische Chemie, Universität Wien, Währingerstrasse 17, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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