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pubmed-article:12076840pubmed:abstractTextClobazam (CLB, 1,5-benzodiazepine, 1,5-BZP) has been reported to show unique antiepileptic action profile distinguishing from standard 1,4-BZPs. To further elucidate the action profile of CLB, its effects on the abnormal circling fits (ACFs) and generalized tonic-clonic convulsions (GTCs) in Ihara epileptic rats (IERs), a genetically epileptic mutant, were examined in comparison with conventional antiepileptic drugs (AEDs), a 1,4-BZP, clonazepam (CZP) and a non-BZP, zonisamide (ZNS).lld:pubmed
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pubmed-article:12076840pubmed:pagination189-202lld:pubmed
pubmed-article:12076840pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:12076840pubmed:articleTitleClobazam shows a different antiepileptic action profile from clonazepam and zonisamide in Ihara epileptic rats.lld:pubmed
pubmed-article:12076840pubmed:affiliationSafety Research Laboratories, Department of Safety Pharmacology, Dainippon Pharmaceutical Co., Ltd., 33-94 Enoki-cho, Suita, Osaka, Japan. yoshiki-miura@dainippon-pharm.co.jplld:pubmed
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