pubmed:abstractText |
Clobazam (CLB, 1,5-benzodiazepine, 1,5-BZP) has been reported to show unique antiepileptic action profile distinguishing from standard 1,4-BZPs. To further elucidate the action profile of CLB, its effects on the abnormal circling fits (ACFs) and generalized tonic-clonic convulsions (GTCs) in Ihara epileptic rats (IERs), a genetically epileptic mutant, were examined in comparison with conventional antiepileptic drugs (AEDs), a 1,4-BZP, clonazepam (CZP) and a non-BZP, zonisamide (ZNS).
|
pubmed:affiliation |
Safety Research Laboratories, Department of Safety Pharmacology, Dainippon Pharmaceutical Co., Ltd., 33-94 Enoki-cho, Suita, Osaka, Japan. yoshiki-miura@dainippon-pharm.co.jp
|