Source:http://linkedlifedata.com/resource/pubmed/id/12076167
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
13
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| pubmed:dateCreated |
2002-6-21
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| pubmed:abstractText |
The synthesis of (Z)-4-hydroxytamoxifen and (Z)-2-[4-[1-(p-hydroxyphenyl)-2-phenyl]-1-butenyl]phenoxyacetic acid was accomplished using a McMurry reaction as the key step. The perfluorotolyl derivatives of the McMurry products enabled the separation of the minor undesirable geometrical isomer. The methodology proceeds without E,Z isomerization, employs a very mild final debenzylation step compatible with a large array of functional groups, and can be applied to the generation of a variety of 4-hydroxytamoxifen analogues.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-3263
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
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| pubmed:volume |
67
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4608-11
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| pubmed:meshHeading |
pubmed-meshheading:12076167-Acetic Acids,
pubmed-meshheading:12076167-Catalysis,
pubmed-meshheading:12076167-Chemistry, Organic,
pubmed-meshheading:12076167-Magnetic Resonance Spectroscopy,
pubmed-meshheading:12076167-Molecular Conformation,
pubmed-meshheading:12076167-Molecular Structure,
pubmed-meshheading:12076167-Stereoisomerism,
pubmed-meshheading:12076167-Tamoxifen
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Synthesis of (Z)-4-hydroxytamoxifen and (Z)-2-[4-[1-(p-hydroxyphenyl)-2-phenyl]-1butenyl]phenoxyacetic acid.
|
| pubmed:affiliation |
Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.
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| pubmed:publicationType |
Journal Article
|