12070281

Source:http://linkedlifedata.com/resource/pubmed/id/12070281

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021764, umls-concept:C0025260, umls-concept:C0031437, umls-concept:C0039194, umls-concept:C0079411, umls-concept:C0085358, umls-concept:C0181586, umls-concept:C1332717, umls-concept:C1413244, umls-concept:C1514559, umls-concept:C1706438, umls-concept:C2698600
pubmed:issue	12
pubmed:dateCreated	2002-6-18
pubmed:abstractText	Transgenic (TG) mice expressing a high copy number of interleukin (IL)-7 cDNA under the control of the major histocomaptability complex (MHC) class II promoter display a 10-20-fold increase in total T cell numbers. Here, we show that the increase in T cell numbers in IL-7 TG mice is most apparent at the level of memory phenotype CD44hi CD122hi CD8+ cells. Based on studies with T cell receptor (TCR) TG mice crossed to IL-7 TG mice, increased levels of IL-7 may provide costimulation for TCR recognition of self-MHC ligands and thus cause naive CD8+ cells to proliferate and differentiate into memory phenotype cells. In addition, a marked increase in CD44hi CD122hi CD8+ cells was found in IL-7 TG IL-15(-) mice. Since these cell are rare in normal IL-15(-) mice, the dependency of memory phenotype CD8+ cells on IL-15 can be overcome by overexpression of IL-7.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AG20186, http://linkedlifedata.com/resource/pubmed/grant/AI07244, http://linkedlifedata.com/resource/pubmed/grant/AI21487, http://linkedlifedata.com/resource/pubmed/grant/AI41079, http://linkedlifedata.com/resource/pubmed/grant/AI45809, http://linkedlifedata.com/resource/pubmed/grant/AI46710, http://linkedlifedata.com/resource/pubmed/grant/CA38355, http://linkedlifedata.com/resource/pubmed/grant/HL07196
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-10485652, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-10485653, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-10558996, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-10558997, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-10580495, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-10704459, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-10784451, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-10881175, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-10952731, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-11062503, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-11207251, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-11447288, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-11550008, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-12070294, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-1712810, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-1836010, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-1918958, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-1988959, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-1999226, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-2522498, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-3259677, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-7678850, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-7699333, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-7769137, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-7794820, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-7964471, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-8145034, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-8207207, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-8312231, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-8415665, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-9168399, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-9620680, http://linkedlifedata.com/resource/pubmed/commentcorrection/12070281-9846488
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985109R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0022-1007
pubmed:author	pubmed-author:Bondi-BoydBreaB, pubmed-author:CeredigRhodriR, pubmed-author:GapinLaurentL, pubmed-author:KieperWilliam CWC, pubmed-author:SprentJonathanJ, pubmed-author:SurhCharles DCD, pubmed-author:TanJoyce TJT
pubmed:issnType	Print
pubmed:day	17
pubmed:volume	195
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1533-9
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:12070281-Animals, pubmed-meshheading:12070281-CD8-Positive T-Lymphocytes, pubmed-meshheading:12070281-Flow Cytometry, pubmed-meshheading:12070281-Immunologic Memory, pubmed-meshheading:12070281-Immunophenotyping, pubmed-meshheading:12070281-Interleukin-15, pubmed-meshheading:12070281-Interleukin-7, pubmed-meshheading:12070281-Mice, pubmed-meshheading:12070281-Mice, Inbred C57BL, pubmed-meshheading:12070281-Mice, Transgenic
pubmed:year	2002
pubmed:articleTitle	Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells.
pubmed:affiliation	Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't