Linked Life Data

12062533

Source:http://linkedlifedata.com/resource/pubmed/id/12062533

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-6-13
pubmed:abstractText
Individual types of retinal nerve cell are spaced across the retina in an orderly manner, ensuring a uniform sampling of the visual field. This regularity in cellular spacing has been commonly attributed to fate determination mechanisms operating around the time of cell birth, an hypothesis presuming that the position of a nerve cell is fixed within the plane of the retina from the time of its determination. At odds with this view, recent results from X-inactivation mosaic mice indicate that certain classes of retinal nerve cell, those known to form orderly mosaics in the adult retina, disperse tangentially during development. Furthermore, studies defining the spatial characteristics of developing and mature retinal mosaics suggest that cell-cell interactions around the time of morphological differentiation lead to mutual repulsion. Modelling studies in turn show that nothing more than a simple minimal spacing rule between neighboring cells of the same type is sufficient for the creation of the global patterning observed in biological retinal mosaics. For some cell types, the size of this "exclusion zone" surrounding individual cells is shown to be an intrinsic characteristic of each cell type, invariant across the retina, and accounting for the variation in mosaic regularity across changes in cell density. These results show how short-distance movements driven by intercellular interactions at the local level may mediate the emergence of the global patterning characteristic of retinal mosaics during development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1350-9462
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-68
pubmed:dateRevised
2009-1-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The role of tangential dispersion in retinal mosaic formation.
pubmed:affiliation
Neuroscience Research Institute and Department of Psychology, University of California, Santa Barbara, CA 93106-5060, USA. breese@psych.ucsb.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't