| pubmed-article:12061837 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C0126732 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C0225698 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:12061837 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:12061837 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12061837 | pubmed:dateCreated | 2002-6-13 | lld:pubmed |
| pubmed-article:12061837 | pubmed:abstractText | The signaling transduction mechanism mediated by tumor necrosis factor-alpha (TNF-alpha) in the alveolar epithelium is not well characterized. It was subsequently hypothesized that recombinant murine TNF-alpha (rmTNF-alpha) selectively regulates the inhibitory kappa B (I kappa B-alpha)/nuclear factor-kappa B (NF-kappa B) pathway and interferes with the endogenous biosynthesis of pro-inflammatory (stimulatory) and anti-inflammatory (inhibitory) cytokines. The cytokine rmTNF-alpha induced, in a time- and dose-dependent manner, the degradation of I kappa B-alpha within the cytosolic compartment, an effect associated with up-regulating its phosphorylation. This allowed the biphasic regulation of selective NF-kappa B subunit nuclear translocation, thereby mediating a dual excitatory mechanism on NF-kappa B activation. The immunoregulatory effect of rmTNF-alpha was associated with a time-dependent induction of pro-inflammatory [interleukin (IL)-1 beta, IL-6 and TNF-alpha] and anti-inflammatory (IL-10) cytokine biosynthesis. These results indicate a novel involvement of an I kappa B-alpha/NF-kappa B-sensitive pathway mediating the effect of TNF-alpha, which is associated with an autocrine, endogenous mechanism mediating the regulation of cytokine signaling. | lld:pubmed |
| pubmed-article:12061837 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12061837 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061837 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12061837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12061837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061837 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12061837 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12061837 | pubmed:issn | 1043-4666 | lld:pubmed |
| pubmed-article:12061837 | pubmed:author | pubmed-author:HaddadJohn... | lld:pubmed |
| pubmed-article:12061837 | pubmed:copyrightInfo | Copyright 2002 Elsevier Science Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:12061837 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12061837 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:12061837 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:12061837 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12061837 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12061837 | pubmed:pagination | 301-10 | lld:pubmed |
| pubmed-article:12061837 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12061837 | pubmed:meshHeading | pubmed-meshheading:12061837... | lld:pubmed |
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| pubmed-article:12061837 | pubmed:meshHeading | pubmed-meshheading:12061837... | lld:pubmed |
| pubmed-article:12061837 | pubmed:meshHeading | pubmed-meshheading:12061837... | lld:pubmed |
| pubmed-article:12061837 | pubmed:meshHeading | pubmed-meshheading:12061837... | lld:pubmed |
| pubmed-article:12061837 | pubmed:meshHeading | pubmed-meshheading:12061837... | lld:pubmed |
| pubmed-article:12061837 | pubmed:meshHeading | pubmed-meshheading:12061837... | lld:pubmed |
| pubmed-article:12061837 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12061837 | pubmed:articleTitle | Recombinant TNF-alpha mediated regulation of the I kappa B-alpha/NF-kappa B signaling pathway: evidence for the enhancement of pro- and anti-inflammatory cytokines in alveolar epithelial cells. | lld:pubmed |
| pubmed-article:12061837 | pubmed:affiliation | Neuroscience Research Laboratory, Department of Anesthesia & Perioperative Care, University of California, Medical Center S-261, San Francisco, California 94143-0542, USA. haddadj@anesthesia.ucsf.edu | lld:pubmed |
| pubmed-article:12061837 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12061837 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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