Linked Life Data

12060766

Source:http://linkedlifedata.com/resource/pubmed/id/12060766

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2002-6-12
pubmed:databankReference
pubmed:abstractText
Myelin/oligodendrocyte glycoprotein (MOG) is a target antigen for myelin-destructive Abs in autoimmune central nervous system demyelinating disorders. Little is known about the molecular and structural basis of these pathogenic Ab responses. Here, we have characterized anti-MOG Ab specificities in the marmoset model of experimental allergic encephalomyelitis, by means of a combinatorial IgG-Fab library. We found that a diverse population of Ig genes encodes for auto-Abs that exclusively recognize conformation-dependent antigenic targets on MOG. These antigenic domains correspond to exposed epitopes in vivo, as the Fab fragments recognize native MOG in situ in marmoset brain tissue. The Ab fragments described here represent Ab specificities that are common constituents of the humoral immune repertoire against MOG in outbred populations, as demonstrated by their ability to displace native anti-MOG Abs present in sera from MOG-immune marmosets and patients with multiple sclerosis. Furthermore, neuropathological analysis and characterization of Ab epitope specificities in animals immunized with MOG or MOG-derived peptides revealed that only conformation-dependent Abs are associated with demyelinating activity, suggesting that epitope recognition is an important factor for Ab pathogenicity. Our findings provide novel and unexpected knowledge on the diversity of anti-MOG Ab responses in nonhuman primates and humans, and will permit the dissection of pathogenic auto-Ab properties in multiple sclerosis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-10190821, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-10229114, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-10408984, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-10528220, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-10545390, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-10679121, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-11108928, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-11169409, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-11240035, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-11403222, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-11592070, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-11596131, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-11895369, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-1453482, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-1899688, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-1991822, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-2462020, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-2539562, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-3500978, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-4118873, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-7525700, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-7684687, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-8557821, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-8675668, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-8864282, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-8943561, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-8953031, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-9183256, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-9485065, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-9727074, http://linkedlifedata.com/resource/pubmed/commentcorrection/12060766-9930864
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8207-12
pubmed:dateRevised
2010-9-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination.
pubmed:affiliation
Department of Neurology, University of California San Francisco, Box 0114, 505 Parnassus Avenue, San Francisco, CA 94143-0114, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't