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pubmed-article:12060439pubmed:abstractTextPatients with high-grade transitional-cell carcinoma (TCC) of the bladder frequently experience recurrence and progress and have a low response rate to chemotherapy in metastatic TCC. In this study, we evaluated the feasibility and long-term efficacy of suicide-gene therapy using adenovirus (Ad)-mediated herpes simplex virus thymidine kinase gene (HSV-TK) and prodrug ganciclovir (GCV) as a potential therapeutic approach in murine-orthotopic models of TCC.lld:pubmed
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pubmed-article:12060439pubmed:authorpubmed-author:ParkHong...lld:pubmed
pubmed-article:12060439pubmed:authorpubmed-author:KimJe JongJJlld:pubmed
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pubmed-article:12060439pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12060439pubmed:articleTitleAdenovirus-mediated suicide-gene therapy in an orthotopic murine bladder tumor model.lld:pubmed
pubmed-article:12060439pubmed:affiliationDepartment of Urology, Korea University College of Medicine, Seoul, Korea. jcheon@ns.kumc.or.krlld:pubmed
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