Linked Life Data

12059022

Source:http://linkedlifedata.com/resource/pubmed/id/12059022

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2002-6-12
pubmed:abstractText
Paclitaxel (Taxol)-containing chitin and chitin-Pluronic F-108 microparticles were formulated as biodegradable systems for localized administration in solid tumors. The microparticles were characterized by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), and swelling studies in phosphate-buffered saline (PBS, pH 7.4). Lysozyme-induced degradation and in vitro release of paclitaxel was examined in PBS at 37 degrees C. The percent change in tumor volume was used to assess efficacy of the Formulations after local administration in murine Lewis lung carcinoma model. FT-IR confirmed higher degree of acetylation in chitin microparticles from the starting chitosan sample and the SEM showed that the chitin-Pluronic F-108 microparticles were significantly more porous than chitin microparticles. Due to higher porosity, chitin-Pluronic microparticles were able to imbibe higher swelling medium and degraded much faster in the presence of lysozyme than chitin microparticles. After 48 h. 51% of incorporated paclitaxel was released from chitin-Pluronic microparticles as compared to 28% from chitin microparticles. In vivo studies in Lewis lung carcinoma-bearing mice showed that the tumor volumes after 6 days using paclitaxel-loaded chitin and chitin-Pluronic F-108 microparticles was 458 and 307 mm3, respectively. In contrast, the tumor volume was 997 mm3 for the untreated control. The results of this study show that chitin and chitin-Pluronic F-108 microparticles are biodegradable drug delivery systems that can be useful for localized delivery of paclitaxel in solid tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2723-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12059022-Acetylglucosamine, pubmed-meshheading:12059022-Animals, pubmed-meshheading:12059022-Antineoplastic Agents, Phytogenic, pubmed-meshheading:12059022-Biocompatible Materials, pubmed-meshheading:12059022-Biodegradation, Environmental, pubmed-meshheading:12059022-Chitin, pubmed-meshheading:12059022-Drug Delivery Systems, pubmed-meshheading:12059022-Female, pubmed-meshheading:12059022-Mice, pubmed-meshheading:12059022-Mice, Inbred C57BL, pubmed-meshheading:12059022-Microscopy, Electron, Scanning, pubmed-meshheading:12059022-Microspheres, pubmed-meshheading:12059022-Muramidase, pubmed-meshheading:12059022-Neoplasms, pubmed-meshheading:12059022-Neoplasms, Experimental, pubmed-meshheading:12059022-Paclitaxel, pubmed-meshheading:12059022-Poloxamer, pubmed-meshheading:12059022-Rats, pubmed-meshheading:12059022-Spectroscopy, Fourier Transform Infrared, pubmed-meshheading:12059022-Surface-Active Agents, pubmed-meshheading:12059022-Temperature, pubmed-meshheading:12059022-Time Factors, pubmed-meshheading:12059022-Tumor Cells, Cultured
pubmed:year
2002
pubmed:articleTitle
Localized delivery of paclitaxel in solid tumors from biodegradable chitin microparticle formulations.
pubmed:affiliation
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't