Linked Life Data

12057793

Source:http://linkedlifedata.com/resource/pubmed/id/12057793

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-6-11
pubmed:abstractText
The present study was undertaken to evaluate the dose-dependent effects of a leaf extract of Stephania hernandifolia on testicular activities in albino rats. Whether this leaf extract has any toxic effect on metabolic organs or on the liver or kidney was studied. Adult male Wistar rats, maintained under standard laboratory conditions, were forcefully fed with the aqueous extract of these leaves at the dose of 2 g or 4 g of leaves/mL distilled water/100 g body weight/day for 28 days. All the animals, along with vehicle-treated controls, were killed on the Day 29 of the experiment. Treatment with this leaf extract at both doses resulted in significant reduction in relative weight in the testis, the seminal vesicles, the prostate, and the epididymis without any significant change in the liver and kidney weight in comparison to control. Activities of testicular steroidogenic key enzymes and plasma testosterone level were decreased significantly, along with a significant reduction in the number of germ cells at stage VII of the spermatogenic cycle and in the seminiferous tubular diameter in both treated groups in comparison to control. Activities of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, acid phosphatase, and alkaline phosphatase were not altered significantly in the liver and kidney in both treated groups compared with controls. We concluded that treatment with an aqueous extract of leaves resulted in diminution in the activities of testicular androgenic key enzymes and plasma level of testosterone along with inhibition of spermatogenesis without any induction of hepatic and renal toxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0010-7824
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
379-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Effects of leaf extract of Stephania hernandifolia on testicular gametogenesis and androgenesis in albino rats: a dose-dependent response study.
pubmed:affiliation
Reproductive Endocrinology and Family Welfare Unit, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore, 721 102, West Bengal, India. debidasghosh@yahoo.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't