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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2002-6-10
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pubmed:abstractText |
In rats with portal vein stenosis, the initial cause of aortic nitric oxide (NO) overproduction might be overactivation of endothelial NO synthase (eNOS) related to increased shear stress. Cardiac output is higher in cirrhosis than in extrahepatic portal hypertension. The aims of this study were to evaluate the role of shear stress, vascular endothelial growth factor (VEGF), and cytokines in aortic eNOS up-regulation in rats with biliary cirrhosis and to compare these results with those in rats with portal vein stenosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1869-77
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12055594-Animals,
pubmed-meshheading:12055594-Aorta,
pubmed-meshheading:12055594-Constriction, Pathologic,
pubmed-meshheading:12055594-Endothelial Growth Factors,
pubmed-meshheading:12055594-HSP90 Heat-Shock Proteins,
pubmed-meshheading:12055594-Liver Cirrhosis, Biliary,
pubmed-meshheading:12055594-Lymphokines,
pubmed-meshheading:12055594-Male,
pubmed-meshheading:12055594-Nitric Oxide Synthase,
pubmed-meshheading:12055594-Nitric Oxide Synthase Type III,
pubmed-meshheading:12055594-Portal Vein,
pubmed-meshheading:12055594-Rats,
pubmed-meshheading:12055594-Rats, Sprague-Dawley,
pubmed-meshheading:12055594-Reference Values,
pubmed-meshheading:12055594-Stress, Mechanical,
pubmed-meshheading:12055594-Up-Regulation,
pubmed-meshheading:12055594-Vascular Endothelial Growth Factor A,
pubmed-meshheading:12055594-Vascular Endothelial Growth Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Role of shear stress in aortic eNOS up-regulation in rats with biliary cirrhosis.
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pubmed:affiliation |
Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, Hôpital Beaujon, Clichy, France. ktazi@bichat.inserm.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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