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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0040558,
umls-concept:C0152060,
umls-concept:C0205154,
umls-concept:C0683598,
umls-concept:C0851285,
umls-concept:C1306235,
umls-concept:C1417530,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1819439
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pubmed:issue |
12
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pubmed:dateCreated |
2002-6-10
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pubmed:abstractText |
Host resistance to the intracellular protozoan Toxoplasma gondii is highly dependent on early IL-12 production by APC. We demonstrate here that both host resistance and T. gondii-induced IL-12 production are dramatically reduced in mice lacking the adaptor molecule MyD88, an important signaling element used by Toll-like receptor (TLR) family members. Infection of MyD88-deficient mice with T. gondii resulted in uncontrolled parasite replication and greatly reduced plasma IL-12 levels. Defective IL-12 responses to T. gondii Ags (soluble tachyzoite Ag (STAg)) were observed in MyD88(-/-) peritoneal macrophages, neutrophils, and splenic dendritic cells (DC). In contrast, DC from TLR2- or TLR4-deficient animals developed normal IL-12 responses to STAg. In vivo treatment with pertussis toxin abolished the residual IL-12 response displayed by STAg-stimulated DC from MyD88(-/-) mice. Taken together, these data suggest that the induction of IL-12 by T. gondii depends on a unique mechanism involving both MyD88 and G protein-coupled signaling pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myd88 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5997-6001
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12055206-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12055206-Animals,
pubmed-meshheading:12055206-Antigens, Differentiation,
pubmed-meshheading:12055206-Dendritic Cells,
pubmed-meshheading:12055206-Drosophila Proteins,
pubmed-meshheading:12055206-Female,
pubmed-meshheading:12055206-Immunity, Innate,
pubmed-meshheading:12055206-Interferon-gamma,
pubmed-meshheading:12055206-Interleukin-12,
pubmed-meshheading:12055206-Macrophages, Peritoneal,
pubmed-meshheading:12055206-Male,
pubmed-meshheading:12055206-Membrane Glycoproteins,
pubmed-meshheading:12055206-Mice,
pubmed-meshheading:12055206-Mice, Inbred C57BL,
pubmed-meshheading:12055206-Mice, Knockout,
pubmed-meshheading:12055206-Myeloid Differentiation Factor 88,
pubmed-meshheading:12055206-Neutrophils,
pubmed-meshheading:12055206-Receptors, CCR5,
pubmed-meshheading:12055206-Receptors, Cell Surface,
pubmed-meshheading:12055206-Receptors, Immunologic,
pubmed-meshheading:12055206-Signal Transduction,
pubmed-meshheading:12055206-Toll-Like Receptor 2,
pubmed-meshheading:12055206-Toll-Like Receptor 4,
pubmed-meshheading:12055206-Toll-Like Receptors,
pubmed-meshheading:12055206-Toxoplasma,
pubmed-meshheading:12055206-Toxoplasmosis, Animal
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pubmed:year |
2002
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pubmed:articleTitle |
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.
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pubmed:affiliation |
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. cscanga@niaid.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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