| pubmed-article:12055204 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12055204 | lifeskim:mentions | umls-concept:C0034085 | lld:lifeskim |
| pubmed-article:12055204 | lifeskim:mentions | umls-concept:C1411976 | lld:lifeskim |
| pubmed-article:12055204 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12055204 | lifeskim:mentions | umls-concept:C1306235 | lld:lifeskim |
| pubmed-article:12055204 | lifeskim:mentions | umls-concept:C0152060 | lld:lifeskim |
| pubmed-article:12055204 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:12055204 | lifeskim:mentions | umls-concept:C0205154 | lld:lifeskim |
| pubmed-article:12055204 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12055204 | pubmed:dateCreated | 2002-6-10 | lld:pubmed |
| pubmed-article:12055204 | pubmed:abstractText | The collectin surfactant protein-A (SP-A) is involved in the innate host defense and the regulation of inflammatory processes in the lung. In this work we investigated the molecular mechanisms related to the immunostimulatory activity of SP-A using macrophages from C3H/HeJ mice, which carry an inactivating mutation in the Toll-like receptor (TLR)4 gene, and TLR4-transfected Chinese hamster ovary cells. We demonstrate that SP-A-induced activation of the NF-kappaB signaling pathway and up-regulation of cytokine synthesis such as TNF-alpha and IL-10 are critically dependent on the TLR4 functional complex. These findings support the concept that TLR4 is a pattern recognition receptor that signals in response to both foreign pathogens and endogenous host mediators. | lld:pubmed |
| pubmed-article:12055204 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055204 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12055204 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12055204 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12055204 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12055204 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12055204 | pubmed:author | pubmed-author:GolenbockDoug... | lld:pubmed |
| pubmed-article:12055204 | pubmed:author | pubmed-author:McCormackFran... | lld:pubmed |
| pubmed-article:12055204 | pubmed:author | pubmed-author:ChignardMiche... | lld:pubmed |
| pubmed-article:12055204 | pubmed:author | pubmed-author:GuillotLoïcL | lld:pubmed |
| pubmed-article:12055204 | pubmed:author | pubmed-author:BalloyViviane... | lld:pubmed |
| pubmed-article:12055204 | pubmed:author | pubmed-author:Si-TaharMusta... | lld:pubmed |
| pubmed-article:12055204 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12055204 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12055204 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:12055204 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12055204 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12055204 | pubmed:pagination | 5989-92 | lld:pubmed |
| pubmed-article:12055204 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12055204 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12055204 | pubmed:articleTitle | Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. | lld:pubmed |
| pubmed-article:12055204 | pubmed:affiliation | Unité de Défense Innée et Inflammation, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale, Unité 485, Paris, France. | lld:pubmed |
| pubmed-article:12055204 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12055204 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12055204 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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