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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-6-10
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pubmed:abstractText |
The collectin surfactant protein-A (SP-A) is involved in the innate host defense and the regulation of inflammatory processes in the lung. In this work we investigated the molecular mechanisms related to the immunostimulatory activity of SP-A using macrophages from C3H/HeJ mice, which carry an inactivating mutation in the Toll-like receptor (TLR)4 gene, and TLR4-transfected Chinese hamster ovary cells. We demonstrate that SP-A-induced activation of the NF-kappaB signaling pathway and up-regulation of cytokine synthesis such as TNF-alpha and IL-10 are critically dependent on the TLR4 functional complex. These findings support the concept that TLR4 is a pattern recognition receptor that signals in response to both foreign pathogens and endogenous host mediators.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Proteolipids,
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactant-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactant-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactants,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5989-92
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12055204-Adjuvants, Immunologic,
pubmed-meshheading:12055204-Animals,
pubmed-meshheading:12055204-Bone Marrow Cells,
pubmed-meshheading:12055204-CHO Cells,
pubmed-meshheading:12055204-Cricetinae,
pubmed-meshheading:12055204-Cytokines,
pubmed-meshheading:12055204-Drosophila Proteins,
pubmed-meshheading:12055204-Female,
pubmed-meshheading:12055204-Humans,
pubmed-meshheading:12055204-Macrophages,
pubmed-meshheading:12055204-Membrane Glycoproteins,
pubmed-meshheading:12055204-Mice,
pubmed-meshheading:12055204-Mice, Inbred C3H,
pubmed-meshheading:12055204-NF-kappa B,
pubmed-meshheading:12055204-Proteolipids,
pubmed-meshheading:12055204-Pulmonary Surfactant-Associated Protein A,
pubmed-meshheading:12055204-Pulmonary Surfactant-Associated Proteins,
pubmed-meshheading:12055204-Pulmonary Surfactants,
pubmed-meshheading:12055204-Receptors, Cell Surface,
pubmed-meshheading:12055204-Signal Transduction,
pubmed-meshheading:12055204-Toll-Like Receptor 4,
pubmed-meshheading:12055204-Toll-Like Receptors,
pubmed-meshheading:12055204-U937 Cells
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pubmed:year |
2002
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pubmed:articleTitle |
Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4.
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pubmed:affiliation |
Unité de Défense Innée et Inflammation, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale, Unité 485, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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