Linked Life Data

12050908

Source:http://linkedlifedata.com/resource/pubmed/id/12050908

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-6-7
pubmed:abstractText
The use of combinations of antiretroviral drugs can profoundly suppress HIV replication for prolonged periods and has substantially decreased AIDS-related morbidity and mortality. The optimal use of antiretroviral drugs remains a rapidly evolving field and numerous obstacles need to be addressed. Many regimens are associated with substantial toxicity, large pill burdens and high cost. In addition, it has become clear that currently available regimens cannot completely suppress HIV replication. Nevertheless, the goal of antiretroviral therapy remains the suppression of plasma viremia as much as possible for as long as possible. Additional goals of therapy include restoration and preservation of immune function, minimization of toxicity, to prevent the disruption of lifestyle and the emergence of drug-resistance virus strains. In some patients a sustained elevations in CD4 cell counts occur despite incomplete viral suppression during HAART. The optimal therapeutic approach in these patients is still unclear. If, as it is generally assumed, viral load determinations reflect ongoing viral replication, then the evolution of drug resistance might be expected. Thus, to prevent the emergence of multidrug resistance, also in these patients a change to a salvage therapy is a viable option.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0034-1193
pubmed:author
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
285-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[Antiretroviral therapy].
pubmed:affiliation
Istituto di Malattie Infettive, Università Tor Vergata, Roma.
pubmed:publicationType
Journal Article, English Abstract