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rdf:type |
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lifeskim:mentions |
umls-concept:C0002144,
umls-concept:C0014257,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0030705,
umls-concept:C0043317,
umls-concept:C0264716,
umls-concept:C0425710,
umls-concept:C0542341,
umls-concept:C0599724,
umls-concept:C1274040,
umls-concept:C1280500
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pubmed:issue |
22
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|
pubmed:dateCreated |
2002-6-4
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|
pubmed:abstractText |
In patients with chronic heart failure (CHF), hyperuricemia is a common finding and is associated with reduced vasodilator capacity and impaired peripheral blood flow. It has been suggested that the causal link of this association is increased xanthine oxidase (XO)-derived oxygen free radical production and endothelial dysfunction. We therefore studied the effects of XO inhibition with allopurinol on endothelial function and peripheral blood flow in CHF patients after intra-arterial infusion and after oral administration in 2 independent placebo-controlled studies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2619-24
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12045167-Administration, Oral,
pubmed-meshheading:12045167-Aged,
pubmed-meshheading:12045167-Allantoin,
pubmed-meshheading:12045167-Allopurinol,
pubmed-meshheading:12045167-Blood Flow Velocity,
pubmed-meshheading:12045167-Chronic Disease,
pubmed-meshheading:12045167-Cross-Over Studies,
pubmed-meshheading:12045167-Double-Blind Method,
pubmed-meshheading:12045167-Endothelium, Vascular,
pubmed-meshheading:12045167-Enzyme Inhibitors,
pubmed-meshheading:12045167-Forearm,
pubmed-meshheading:12045167-Heart Failure,
pubmed-meshheading:12045167-Humans,
pubmed-meshheading:12045167-Infusions, Intra-Arterial,
pubmed-meshheading:12045167-Male,
pubmed-meshheading:12045167-Middle Aged,
pubmed-meshheading:12045167-Oxidative Stress,
pubmed-meshheading:12045167-Regional Blood Flow,
pubmed-meshheading:12045167-Uric Acid,
pubmed-meshheading:12045167-Vasodilation,
pubmed-meshheading:12045167-Xanthine Oxidase
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pubmed:year |
2002
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pubmed:articleTitle |
Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies.
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pubmed:affiliation |
Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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