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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-5-30
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pubmed:abstractText |
It has been reported that 17beta-estradiol (E2) may enhance the proliferation of bovine retinal vascular endothelial cells (BRECs) by increasing the expression of VEGFR-2 and VEGF. The hypothesis in the current study was that estrogen may contribute to fetal vascular development and the cessation of exposure to estrogen of premature infants on birth may have an inhibitory effect on retinopathy of prematurity (ROP). Because ROP is thought to develop under relative hypoxia after exposure to high-dose oxygen, this study was conducted to investigate how estrogen modulates hypoxia-induced VEGF in BRECs and mouse ROP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hif1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tamoxifen,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2007-14
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12037012-Animals,
pubmed-meshheading:12037012-Anoxia,
pubmed-meshheading:12037012-Blotting, Northern,
pubmed-meshheading:12037012-Cattle,
pubmed-meshheading:12037012-Cells, Cultured,
pubmed-meshheading:12037012-DNA-Binding Proteins,
pubmed-meshheading:12037012-Dose-Response Relationship, Drug,
pubmed-meshheading:12037012-Drug Combinations,
pubmed-meshheading:12037012-Endothelial Growth Factors,
pubmed-meshheading:12037012-Endothelium, Vascular,
pubmed-meshheading:12037012-Estrogens,
pubmed-meshheading:12037012-Gene Expression Regulation,
pubmed-meshheading:12037012-Humans,
pubmed-meshheading:12037012-Hypoxia-Inducible Factor 1,
pubmed-meshheading:12037012-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:12037012-Infant, Newborn,
pubmed-meshheading:12037012-Lymphokines,
pubmed-meshheading:12037012-Mice,
pubmed-meshheading:12037012-Mice, Inbred C57BL,
pubmed-meshheading:12037012-Models, Animal,
pubmed-meshheading:12037012-Nuclear Proteins,
pubmed-meshheading:12037012-RNA, Messenger,
pubmed-meshheading:12037012-Retinal Neovascularization,
pubmed-meshheading:12037012-Retinal Vessels,
pubmed-meshheading:12037012-Retinopathy of Prematurity,
pubmed-meshheading:12037012-Tamoxifen,
pubmed-meshheading:12037012-Transcription Factors,
pubmed-meshheading:12037012-Vascular Endothelial Growth Factor A,
pubmed-meshheading:12037012-Vascular Endothelial Growth Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Contrasting effect of estrogen on VEGF induction under different oxygen status and its role in murine ROP.
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pubmed:affiliation |
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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