Source:http://linkedlifedata.com/resource/pubmed/id/12034047
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0032520,
umls-concept:C0087111,
umls-concept:C0181904,
umls-concept:C0220847,
umls-concept:C0302350,
umls-concept:C0392762,
umls-concept:C0443252,
umls-concept:C0596972,
umls-concept:C0681890,
umls-concept:C0728873,
umls-concept:C0871261,
umls-concept:C1442457,
umls-concept:C1521743,
umls-concept:C1704632,
umls-concept:C1704646,
umls-concept:C1706817,
umls-concept:C2911692
|
| pubmed:issue |
3
|
| pubmed:dateCreated |
2002-5-29
|
| pubmed:abstractText |
The relation between the change in hepatitis C virus (HCV) RNA levels at the start of interferon-beta (IFN-beta) treatment and the long-term therapeutic response remains poorly defined. In 20 patients with chronic hepatitis C who received IFN-beta (total dose 126-756 MU), the changes in serum HCV RNA during the first 2 weeks of therapy were monitored by real-time quantitative polymerase chain reaction (PCR). The serum HCV RNA level decreased rapidly during the first 24 h of therapy (first phase) and more slowly thereafter (second phase), with a mean exponential decay rate of 1.17 log10/day and 0.37 log10/day, respectively. Three patients had a sustained virologic response, 10 patients had a transient response, and 7 patients had no response. The differences in the rate of first-phase viral decline among the three groups were not significant (p = 0.21), but the differences in the rate of second-phase viral decline were significant (p = 0.0021). The mean decay rate between the end of the first 24 h and day 14 was 0.96 +/- 0.43 log10/day in sustained responders, 0.39 +/- 0.30 log10/day in transient responders, and 0.13 +/- 0.09 log10/day in nonresponders. We conclude that during the first 2 weeks of therapy, changes in serum HCV RNA levels as monitored by real-time quantitative PCR can be used to predict the long-term response to treatment with IFN-beta.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1079-9907
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| pubmed:author |
pubmed-author:EnomotoMasaruM,
pubmed-author:FukudaKatsuhikoK,
pubmed-author:HabuDaikiD,
pubmed-author:NishiguchiShuheiS,
pubmed-author:OtaniShuzoS,
pubmed-author:ShiomiSusumuS,
pubmed-author:TakedaTadashiT,
pubmed-author:TamoriAkihiroA,
pubmed-author:TanakaMotoharuM,
pubmed-author:UedaTadashiT,
pubmed-author:YanoYoshihisaY
|
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
389-95
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12034047-Adult,
pubmed-meshheading:12034047-Antiviral Agents,
pubmed-meshheading:12034047-Female,
pubmed-meshheading:12034047-Genotype,
pubmed-meshheading:12034047-Hepacivirus,
pubmed-meshheading:12034047-Hepatitis C, Chronic,
pubmed-meshheading:12034047-Humans,
pubmed-meshheading:12034047-Interferon-beta,
pubmed-meshheading:12034047-Kinetics,
pubmed-meshheading:12034047-Male,
pubmed-meshheading:12034047-Middle Aged,
pubmed-meshheading:12034047-Monitoring, Physiologic,
pubmed-meshheading:12034047-Polymerase Chain Reaction,
pubmed-meshheading:12034047-Predictive Value of Tests,
pubmed-meshheading:12034047-RNA, Viral,
pubmed-meshheading:12034047-Retrospective Studies,
pubmed-meshheading:12034047-Time Factors,
pubmed-meshheading:12034047-Treatment Outcome
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Dynamics of hepatitis C virus monitored by real-time quantitative polymerase chain reaction during first 2 weeks of IFN-beta treatment are predictive of long-term therapeutic response.
|
| pubmed:affiliation |
Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|