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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-5-24
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pubmed:abstractText |
Several recent epidemiological studies have shown that vaccinations against biological warfare using pertussis as an adjuvant were associated with the Gulf war syndrome. If such epidemiological findings are confirmed, we propose that the use of pertussis as an adjuvant could trigger neurodegeneration through induction of interleukin-1beta secretion in the brain. In turn, neuronal lesions may be sustained by stress or neurotoxic chemical combinations. Particular susceptibility for IL-1beta secretion and potential distant neuronal damage could provide an explanation for the diversity of the symptoms observed on veterans.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0306-9877
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 Elsevier Science Ltd. All rights reserved.
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
291-2
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12027522-Adjuvants, Immunologic,
pubmed-meshheading:12027522-Adult,
pubmed-meshheading:12027522-Blood-Brain Barrier,
pubmed-meshheading:12027522-Brain,
pubmed-meshheading:12027522-Enzyme Activation,
pubmed-meshheading:12027522-Hippocampus,
pubmed-meshheading:12027522-Humans,
pubmed-meshheading:12027522-Interleukin-1,
pubmed-meshheading:12027522-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:12027522-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12027522-Models, Biological,
pubmed-meshheading:12027522-Nerve Degeneration,
pubmed-meshheading:12027522-Nerve Tissue Proteins,
pubmed-meshheading:12027522-Neurons,
pubmed-meshheading:12027522-Persian Gulf Syndrome,
pubmed-meshheading:12027522-Pertussis Vaccine,
pubmed-meshheading:12027522-Vaccination
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pubmed:year |
2002
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pubmed:articleTitle |
Gulf war syndrome: could it be triggered by biological warfare-vaccines using pertussis as an adjuvant?
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pubmed:affiliation |
Département de biologie des agents transmissibles, CRSSA, La Tronche, France. j.tournier@eudoramail.com
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pubmed:publicationType |
Journal Article
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