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pubmed-article:12021548pubmed:abstractTextWe previously reported that the purified Shiga toxins (Stx) Stx1 and Stx2, when coupled with liposomes, induced substantial production of anti-Stx1 and anti-Stx2 IgG antibody, respectively, in mice. The levels of anti-Stx antibody in the sera of mice immune to Stx-liposome correlated well with the protection against subsequent challenge with Stx. Furthermore, mice immunized with a mixture of Stx1-liposome and Stx2-liposome were successfully protected against oral infection with cytotoxin-producing Escherichia coli O157:H7.lld:pubmed
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pubmed-article:12021548pubmed:copyrightInfoCopyright 2002 S. Karger AG, Basellld:pubmed
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pubmed-article:12021548pubmed:articleTitleProtection of monkeys against Shiga toxin induced by Shiga toxin-liposome conjugates.lld:pubmed
pubmed-article:12021548pubmed:affiliationDivision of Experimental Animals Research, Department of Safety Research on Biologics, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan.lld:pubmed
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