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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-5-21
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pubmed:abstractText |
We previously reported that the purified Shiga toxins (Stx) Stx1 and Stx2, when coupled with liposomes, induced substantial production of anti-Stx1 and anti-Stx2 IgG antibody, respectively, in mice. The levels of anti-Stx antibody in the sera of mice immune to Stx-liposome correlated well with the protection against subsequent challenge with Stx. Furthermore, mice immunized with a mixture of Stx1-liposome and Stx2-liposome were successfully protected against oral infection with cytotoxin-producing Escherichia coli O157:H7.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1018-2438
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pubmed:author |
pubmed-author:AmiYasushiY,
pubmed-author:GondairaFumioF,
pubmed-author:KatoHiroshiH,
pubmed-author:KomiyaTakakoT,
pubmed-author:KomuroKatsutoshiK,
pubmed-author:MoriMasahitoM,
pubmed-author:NagataNoriyoN,
pubmed-author:NaitoSeishiroS,
pubmed-author:NakanoYoshioY,
pubmed-author:SatohSachihiroS,
pubmed-author:SugiyamaJunichiJ,
pubmed-author:SuzakiYurikoY,
pubmed-author:TakahashiMotohideM,
pubmed-author:TaneichiMaikoM,
pubmed-author:UchidaTetsuyaT
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pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
294-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12021548-Animals,
pubmed-meshheading:12021548-Antibodies, Bacterial,
pubmed-meshheading:12021548-Colitis,
pubmed-meshheading:12021548-Escherichia coli Infections,
pubmed-meshheading:12021548-Histocytochemistry,
pubmed-meshheading:12021548-Immunization,
pubmed-meshheading:12021548-Intestines,
pubmed-meshheading:12021548-Liposomes,
pubmed-meshheading:12021548-Macaca fascicularis,
pubmed-meshheading:12021548-Shiga Toxin 2
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pubmed:year |
2002
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pubmed:articleTitle |
Protection of monkeys against Shiga toxin induced by Shiga toxin-liposome conjugates.
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pubmed:affiliation |
Division of Experimental Animals Research, Department of Safety Research on Biologics, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan.
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pubmed:publicationType |
Journal Article
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