Linked Life Data

12019563

Source:http://linkedlifedata.com/resource/pubmed/id/12019563

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-5-21
pubmed:abstractText
Visual transduction begins with the detection of light within the photoreceptor cell layer of the retina. Within this layer, specialized cells, termed rods and cones, contain the proteins responsible for light capture and its transduction to nerve impulses. The phototransductive proteins reside within an outer segment region that is connected to an inner segment by a thin stalk rich in cytoskeletal elements. A unique property of the outer segments is the presence of an elaborate intracellular membrane system that holds the phototransduction proteins and provides the requisite lipid environment. The maintenance of normal physiological function requires that these postmitotic cells retain the unique structure of the outer segment regions--stacks of membrane saccules in the case of rods and a continuous infolding of membrane in the case of cones. Both photoreceptor rod and cone cells achieve this through a series of coordinated steps. As new membranous material is synthesized, transported, and incorporated into newly forming outer segment membranes, a compensatory shedding of older membranous material occurs, thereby maintaining the segment at a constant length. These processes are collectively referred to as ROS (rod outer segment) or COS (cone outer segment) renewal. We review the cellular and molecular events responsible for these renewal processes and present the recent but compelling evidence, drawn from molecular genetic, biochemical, and biophysical approaches, pointing to an essential role for a unique tetraspanning membrane protein, called peripherin/rds, in the processes of disk morphogenesis.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-06, http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-07, http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-08, http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-09, http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-10A2, http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-11, http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-12, http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-13A2, http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-14, http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-15, http://linkedlifedata.com/resource/pubmed/grant/R01 EY010420-16, http://linkedlifedata.com/resource/pubmed/grant/R21 EY018705-01A1, http://linkedlifedata.com/resource/pubmed/grant/R21 EY018705-02, http://linkedlifedata.com/resource/pubmed/grant/R29 EY010420-03, http://linkedlifedata.com/resource/pubmed/grant/S10 RR026365-01
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0074-7696
pubmed:author
pubmed:issnType
Print
pubmed:volume
217
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-225
pubmed:dateRevised
2011-10-20
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Photoreceptor renewal: a role for peripherin/rds.
pubmed:affiliation
School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford 08084, USA.
pubmed:publicationType
Journal Article, Review