| pubmed-article:12016203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12016203 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:12016203 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
| pubmed-article:12016203 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:12016203 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:12016203 | lifeskim:mentions | umls-concept:C1510470 | lld:lifeskim |
| pubmed-article:12016203 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12016203 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12016203 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12016203 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12016203 | lifeskim:mentions | umls-concept:C0205266 | lld:lifeskim |
| pubmed-article:12016203 | pubmed:issue | 5574 | lld:pubmed |
| pubmed-article:12016203 | pubmed:dateCreated | 2002-6-7 | lld:pubmed |
| pubmed-article:12016203 | pubmed:abstractText | Lymphocyte motility is vital for trafficking within lymphoid organs and for initiating contact with antigen-presenting cells. Visualization of these processes has previously been limited to in vitro systems. We describe the use of two-photon laser microscopy to image the dynamic behavior of individual living lymphocytes deep within intact lymph nodes. In their native environment, T cells achieved peak velocities of more than 25 micrometers per minute, displaying a motility coefficient that is five to six times that of B cells. Antigenic challenge changed T cell trajectories from random walks to "swarms" and stable clusters. Real-time two-photon imaging reveals lymphocyte behaviors that are fundamental to the initiation of the immune response. | lld:pubmed |
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| pubmed-article:12016203 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12016203 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12016203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12016203 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12016203 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:12016203 | pubmed:author | pubmed-author:CahalanMichae... | lld:pubmed |
| pubmed-article:12016203 | pubmed:author | pubmed-author:ParkerIanI | lld:pubmed |
| pubmed-article:12016203 | pubmed:author | pubmed-author:MillerMark... | lld:pubmed |
| pubmed-article:12016203 | pubmed:author | pubmed-author:WeiSindy HSH | lld:pubmed |
| pubmed-article:12016203 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12016203 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:12016203 | pubmed:volume | 296 | lld:pubmed |
| pubmed-article:12016203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12016203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12016203 | pubmed:pagination | 1869-73 | lld:pubmed |
| pubmed-article:12016203 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:12016203 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12016203 | pubmed:articleTitle | Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. | lld:pubmed |
| pubmed-article:12016203 | pubmed:affiliation | Department of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA. | lld:pubmed |
| pubmed-article:12016203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12016203 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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