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rdf:type |
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lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0025186,
umls-concept:C0026255,
umls-concept:C0036679,
umls-concept:C0237868,
umls-concept:C0242609,
umls-concept:C0851285,
umls-concept:C1334043,
umls-concept:C1439287,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636
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pubmed:issue |
10
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pubmed:dateCreated |
2002-5-16
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pubmed:abstractText |
Mitotic chromosome segregation depends on bi-orientation and capture of sister kinetochores by microtubules emanating from opposite spindle poles and the near synchronous loss of sister chromatid cohesion. During meiosis I, in contrast, sister kinetochores orient to the same pole, and homologous kinetochores are captured by microtubules emanating from opposite spindle poles. Additionally, mechanisms exist that prevent complete loss of cohesion during meiosis I. These features ensure that homologs separate during meiosis I and sister chromatids remain together until meiosis II. The mechanisms responsible for orienting kinetochores in mitosis and for causing asynchronous loss of cohesion during meiosis are not well understood.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AIR-2 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/BIR1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Multiprotein Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/aurora kinase,
http://linkedlifedata.com/resource/pubmed/chemical/condensin complexes
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
798-812
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pubmed:dateRevised |
2011-7-11
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pubmed:meshHeading |
pubmed-meshheading:12015116-Adenosine Triphosphatases,
pubmed-meshheading:12015116-Animals,
pubmed-meshheading:12015116-Caenorhabditis elegans,
pubmed-meshheading:12015116-Caenorhabditis elegans Proteins,
pubmed-meshheading:12015116-Chromatids,
pubmed-meshheading:12015116-Chromosome Segregation,
pubmed-meshheading:12015116-DNA-Binding Proteins,
pubmed-meshheading:12015116-Embryo, Nonmammalian,
pubmed-meshheading:12015116-Epitopes,
pubmed-meshheading:12015116-Helminth Proteins,
pubmed-meshheading:12015116-Histones,
pubmed-meshheading:12015116-In Situ Hybridization, Fluorescence,
pubmed-meshheading:12015116-Kinetochores,
pubmed-meshheading:12015116-Meiosis,
pubmed-meshheading:12015116-Metaphase,
pubmed-meshheading:12015116-Mitosis,
pubmed-meshheading:12015116-Models, Biological,
pubmed-meshheading:12015116-Multiprotein Complexes,
pubmed-meshheading:12015116-Mutation,
pubmed-meshheading:12015116-Phosphoproteins,
pubmed-meshheading:12015116-Protein Binding,
pubmed-meshheading:12015116-Protein-Serine-Threonine Kinases
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pubmed:year |
2002
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pubmed:articleTitle |
The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis.
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pubmed:affiliation |
Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030, Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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