Linked Life Data

12003817

Source:http://linkedlifedata.com/resource/pubmed/id/12003817

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-5-10
pubmed:abstractText
This study evaluates the effects of anesthesia and fluid support on hemodynamic parameters of the mechanically ventilated mouse of four different strains. All experiments were performed at a similar surgical level of anesthesia, as indicated by the probing of the pedal withdrawal reflex. Three anesthetic regimens [fentanyl-fluanisone-midazolam (FFM), ketamine-medetomidine-atropine (KMA), and isoflurane (ISO)], four commonly used mouse strains (Swiss, CD-1, BalbC, and C57Bl6), and three different fluid support strategies (no fluid, 0.2 ml x h(-1) x 10 g(-1) of 6% polystarch solution, and 0.5 ml x h(-1) x 10 g(-1) saline) were studied. Mean arterial pressure (MAP) or heart rate (HR) was similar among the four strains of mice except a trend toward lower HR for the BalbC mice. In terms of MAP, KMA is the preferred anesthetic for the Swiss and CD-1 mice, whereas KMA or ISO are recommended for BalbC or C57Bl6 mice. In terms of HR, ISO is the preferred anesthetic for the Swiss, CD-1, and C57Bl6 strains. No differences in HR for the three anesthetics were observed for the BalbC strain. Compared with administration of no fluid, both saline and polystarch administration similarly increased MAP by 7 +/- 2, 10 +/- 2, and 11 +/- 2 mmHg at t = 1, 2, and 3 h, respectively, whereas fluid administration was without effect on HR. Saline supplementation resulted in an increased dry-to-wet ratio of the heart and both fluid regimens decreased total hemoglobin in the blood from 12.6 +/- 0.5 to 10.4 +/- 0.5 g/100 ml. Saline administration was associated with blood acidosis (pH 7.20 +/- 0.03) compared with the Haes (pH 7.29 +/- 0.02) or no-fluid group (pH 7.34 +/- 0.03), whereas PCO(2) was approximately 30 mmHg for all groups. We conclude that at similar surgical levels of anesthesia, the preferable type of anesthesia (ISO or KMA, but never FFM) depends on the strain used and whether MAP or HR is the focus of study. Additional fluid support is beneficial in terms of raising arterial blood pressure, although this is at the cost of changes in organ water content and increased anemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0363-6135
pubmed:author
pubmed:issnType
Print
pubmed:volume
282
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H2099-105
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:12003817-Anesthesia, pubmed-meshheading:12003817-Anesthetics, pubmed-meshheading:12003817-Animals, pubmed-meshheading:12003817-Atropine, pubmed-meshheading:12003817-Blood Pressure, pubmed-meshheading:12003817-Butyrophenones, pubmed-meshheading:12003817-Fentanyl, pubmed-meshheading:12003817-Fluid Therapy, pubmed-meshheading:12003817-Heart Rate, pubmed-meshheading:12003817-Hemodynamics, pubmed-meshheading:12003817-Isoflurane, pubmed-meshheading:12003817-Ketamine, pubmed-meshheading:12003817-Medetomidine, pubmed-meshheading:12003817-Mice, pubmed-meshheading:12003817-Mice, Inbred BALB C, pubmed-meshheading:12003817-Mice, Inbred C57BL, pubmed-meshheading:12003817-Midazolam, pubmed-meshheading:12003817-Models, Animal, pubmed-meshheading:12003817-Respiration, Artificial, pubmed-meshheading:12003817-Species Specificity
pubmed:year
2002
pubmed:articleTitle
Hemodynamics of anesthetized ventilated mouse models: aspects of anesthetics, fluid support, and strain.
pubmed:affiliation
Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. c.j.zuurbier@amc.uva.nl
pubmed:publicationType
Journal Article