Source:http://linkedlifedata.com/resource/pubmed/id/11996955
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-5-8
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| pubmed:abstractText |
Ageing and atherosclerosis (ATH) are well-known risk factors for erectile dysfunction (ED). To identify the mechanisms implicated in ATH-induced ED, independently of its ageing-associated component, we studied (i) erectile responses in vivo, and, (ii) endothelium-dependent and independent relaxations of corporal strips from young adult (YAD, n=6), adult (AD, n=6), and cholesterol-fed (ATH, n=8) New-Zealand white rabbits. Measurement of Intima/Media (I/M) ratio on iliac arteries from ATH rabbits determined those with moderate (Mod ATH, 0.5+/-0.3) or severe (Sev ATH, 1.5+/-0.4, P<0.05 Mann-Whitney) atherosclerotic lesions. Erectile responses were reduced in AD compared with YAD rabbits (at 6 V to 10 Hz: 51.6+/-4.6% vs. 57.5+/-1.4%); they were similar in AD and mod ATH rabbits (48.1+/-4.6%) but drastically impaired in Sev ATH rabbits (34.8+/-5.4%, P<0.05, two-way analysis of variance (ANOVA)). Corporal endothelium-dependent and -independent relaxations were comparable in YAD and AD rabbits (maximal relaxation to acetylcholine: 51.3+/-9.5 vs. 56.1+/-9.3%) but decreased in ATH rabbits (37.1+/-1.6%, P<0.001, two-way ANOVA). These results suggest that the mechanisms implicated in ATH-induced ED are distinct from the ageing-related process in rabbits. Thus, future therapeutic targets to treat or prevent ATH-induced ED may include the reduction of the atherosclerotic plaque size or progression, as well as an improvement of the smooth muscle and endothelial reactivity of the corpus cavernosum.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0021-9150
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
162
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
355-62
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11996955-Animals,
pubmed-meshheading:11996955-Arteriosclerosis,
pubmed-meshheading:11996955-Erectile Dysfunction,
pubmed-meshheading:11996955-Hypercholesterolemia,
pubmed-meshheading:11996955-Male,
pubmed-meshheading:11996955-Muscle, Smooth,
pubmed-meshheading:11996955-Muscle Relaxation,
pubmed-meshheading:11996955-Penile Erection,
pubmed-meshheading:11996955-Penis,
pubmed-meshheading:11996955-Phenylephrine,
pubmed-meshheading:11996955-Rabbits,
pubmed-meshheading:11996955-Vasoconstrictor Agents
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Distinct mechanisms implicated in atherosclerosis-induced erectile dysfunction in rabbits.
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| pubmed:affiliation |
Pelvipharm, Domaine INRA, Route de la Guyonnerie, 91440, Bures sur Yvette, France.
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| pubmed:publicationType |
Journal Article
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