Linked Life Data

11985378

Source:http://linkedlifedata.com/resource/pubmed/id/11985378

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-5-2
pubmed:abstractText
The diagnosis of Idiopathic Parkinson's disease (IPD) requires post mortem neuropathological confirmation to be secure, since there is marked heterogeneity in the clinical phenotype of these patients. Pathologically confirmed IPD encompasses a spectrum of microscopic appearances with respect to the extent and distribution of Lewy Body deposition, which may reflect the clinical phenotypes observed during life. In this review, we discuss how IPD is currently defined and the purpose and applications of a classification of the disease. We have also performed a systematic review of the literature to present the quantitative evidence on which potential classifications of the disease might be based. This evidence suggests that sub-groups based on age of onset, motor presentation, or subsequent motor phenotype may have some use in predicting disease progression. However, further clinicopathological studies are required to evaluate pathological heterogeneity within these groups. Clinical sub-groups may be related to a variety of as yet unknown risks, including genetic factors for both the familial and sporadic forms of the disease, and may have far reaching consequences for our understanding of disease pathogenesis and treatment strategies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0340-5354
pubmed:author
pubmed:issnType
Print
pubmed:volume
249
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
138-45
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The heterogeneity of idiopathic Parkinson's disease.
pubmed:affiliation
Cambridge Centre for Brain Repair, University of Cambridge, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't