| pubmed-article:11983909 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11983909 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:11983909 | lifeskim:mentions | umls-concept:C0504064 | lld:lifeskim |
| pubmed-article:11983909 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11983909 | lifeskim:mentions | umls-concept:C1705180 | lld:lifeskim |
| pubmed-article:11983909 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:11983909 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11983909 | pubmed:dateCreated | 2002-5-1 | lld:pubmed |
| pubmed-article:11983909 | pubmed:abstractText | The allospecifc T cell population responding to a transplanted organ consists of both naive and memory lymphocytes. Although it is established that naive T cells are activated by antigen within the organized structures of secondary lymphoid organs (the spleen, lymph nodes, and mucosal lymphoid tissues), it is not clear whether memory T cell activation and propagation depend on homing to these organs. To answer this question, we investigated whether allospecific naive or memory T cells can mediate acute cardiac allograft rejection in mutant mice that lack all of their secondary lymphoid tissues. The results of our experiments demonstrated that antigen-experienced memory T cells have two advantages over naive T cells: (i) memory T cells mount a vigorous immune response that leads to allograft rejection independent of secondary lymphoid organs; and (ii) memory T cells generate more memory T cells without homing to secondary lymphoid organs. These unique properties of memory T cells were further confirmed by showing that memory-like T cells that arise from the homeostatic proliferation of naive T cells in the absence of antigenic stimulation are suboptimal at rejecting allografts and do not generate memory T cells in mice devoid of secondary lymphoid tissues. | lld:pubmed |
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| pubmed-article:11983909 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11983909 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11983909 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11983909 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11983909 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11983909 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11983909 | pubmed:author | pubmed-author:ChalasaniGeet... | lld:pubmed |
| pubmed-article:11983909 | pubmed:author | pubmed-author:DaiZhenhuaZ | lld:pubmed |
| pubmed-article:11983909 | pubmed:author | pubmed-author:KoniecznyBogu... | lld:pubmed |
| pubmed-article:11983909 | pubmed:author | pubmed-author:BaddouraFady... | lld:pubmed |
| pubmed-article:11983909 | pubmed:author | pubmed-author:LakkisFadi... | lld:pubmed |
| pubmed-article:11983909 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11983909 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:11983909 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:11983909 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11983909 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11983909 | pubmed:pagination | 6175-80 | lld:pubmed |
| pubmed-article:11983909 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11983909 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11983909 | pubmed:articleTitle | Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs. | lld:pubmed |
| pubmed-article:11983909 | pubmed:affiliation | Section of Nephrology (Department of Medicine) and Section of Immunobiology, Yale University School of Medicine, P.O. Box 208029, 333 Cedar Street, New Haven, CT 06520, USA. | lld:pubmed |
| pubmed-article:11983909 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11983909 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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