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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-5-1
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pubmed:abstractText |
The allospecifc T cell population responding to a transplanted organ consists of both naive and memory lymphocytes. Although it is established that naive T cells are activated by antigen within the organized structures of secondary lymphoid organs (the spleen, lymph nodes, and mucosal lymphoid tissues), it is not clear whether memory T cell activation and propagation depend on homing to these organs. To answer this question, we investigated whether allospecific naive or memory T cells can mediate acute cardiac allograft rejection in mutant mice that lack all of their secondary lymphoid tissues. The results of our experiments demonstrated that antigen-experienced memory T cells have two advantages over naive T cells: (i) memory T cells mount a vigorous immune response that leads to allograft rejection independent of secondary lymphoid organs; and (ii) memory T cells generate more memory T cells without homing to secondary lymphoid organs. These unique properties of memory T cells were further confirmed by showing that memory-like T cells that arise from the homeostatic proliferation of naive T cells in the absence of antigenic stimulation are suboptimal at rejecting allografts and do not generate memory T cells in mice devoid of secondary lymphoid tissues.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10051624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10319865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10438971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10477579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10537110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10557316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10790423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10835686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10925249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10952724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10952725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-10975812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-11069060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-11069289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-11228420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-11242050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-11264538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-11269302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-11560949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-11581317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-11595568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-3261843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-8299692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11983909-9182687
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6175-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11983909-Animals,
pubmed-meshheading:11983909-Cell Transplantation,
pubmed-meshheading:11983909-Flow Cytometry,
pubmed-meshheading:11983909-Immunologic Memory,
pubmed-meshheading:11983909-Immunophenotyping,
pubmed-meshheading:11983909-Lymph Nodes,
pubmed-meshheading:11983909-Mice,
pubmed-meshheading:11983909-Mice, Inbred BALB C,
pubmed-meshheading:11983909-Mucous Membrane,
pubmed-meshheading:11983909-Mutation,
pubmed-meshheading:11983909-Recombination, Genetic,
pubmed-meshheading:11983909-Spleen,
pubmed-meshheading:11983909-T-Lymphocyte Subsets,
pubmed-meshheading:11983909-T-Lymphocytes, Cytotoxic
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pubmed:year |
2002
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pubmed:articleTitle |
Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs.
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pubmed:affiliation |
Section of Nephrology (Department of Medicine) and Section of Immunobiology, Yale University School of Medicine, P.O. Box 208029, 333 Cedar Street, New Haven, CT 06520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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