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pubmed-article:11983298pubmed:abstractTextThere is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.lld:pubmed
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pubmed-article:11983298pubmed:articleTitleApolipoprotein E genotype does not predict decline in intelligence in healthy older adults.lld:pubmed
pubmed-article:11983298pubmed:affiliationClinical Gerontology Group, Clinical Division I, University of Manchester, Hope Hospital, Stott Lane, Salford, M6 8HD, UK. npendlet@fs1.ho.man.ac.uklld:pubmed
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