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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-5-1
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pubmed:abstractText |
There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
324
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11983298-Age Factors,
pubmed-meshheading:11983298-Aged,
pubmed-meshheading:11983298-Aged, 80 and over,
pubmed-meshheading:11983298-Aging,
pubmed-meshheading:11983298-Apolipoprotein E2,
pubmed-meshheading:11983298-Apolipoprotein E4,
pubmed-meshheading:11983298-Apolipoproteins E,
pubmed-meshheading:11983298-Brain,
pubmed-meshheading:11983298-Brain Chemistry,
pubmed-meshheading:11983298-Cognition Disorders,
pubmed-meshheading:11983298-Cohort Studies,
pubmed-meshheading:11983298-DNA Mutational Analysis,
pubmed-meshheading:11983298-Female,
pubmed-meshheading:11983298-Gene Frequency,
pubmed-meshheading:11983298-Genetic Testing,
pubmed-meshheading:11983298-Genotype,
pubmed-meshheading:11983298-Humans,
pubmed-meshheading:11983298-Intelligence,
pubmed-meshheading:11983298-Male,
pubmed-meshheading:11983298-Middle Aged,
pubmed-meshheading:11983298-Models, Statistical,
pubmed-meshheading:11983298-Predictive Value of Tests,
pubmed-meshheading:11983298-Sex Factors,
pubmed-meshheading:11983298-Statistics as Topic
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pubmed:year |
2002
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pubmed:articleTitle |
Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults.
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pubmed:affiliation |
Clinical Gerontology Group, Clinical Division I, University of Manchester, Hope Hospital, Stott Lane, Salford, M6 8HD, UK. npendlet@fs1.ho.man.ac.uk
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pubmed:publicationType |
Journal Article
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