Source:http://linkedlifedata.com/resource/pubmed/id/11973417
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
2002-4-25
|
pubmed:abstractText |
This study investigated whether activated protein C (APC) improves the cerebral vasospasm in an experimental subarachnoid hemorrhage that was produced by the intracisternal injection of autologous blood. Male rabbits were divided into the following four groups: APC 0.1-and 0.5-mg groups, in which 0.1 and 0.5 mg APC were injected into the cisterna magna, respectively; a placebo group, in which saline was injected instead of APC; and a sham operation group that did not get injections of autologous blood, APC, and saline. On day 2, amount of clot in the basal cistern was significantly (p < 0.01) decreased in the APC 0.5-mg group. Percent diameter of the basilar artery on day 2 to that before injecting the blood was angiographically determined as 97.1 +/- 3.8% in the APC 0.5-mg group, which was significantly (p < 0.001) greater than the corresponding value in the placebo group (74.8 +/- 3.4%). The impaired endothelium-dependent relaxation following subarachnoid hemorrhage was normalized in the APC 0.5-mg group (p < 0.0001). These results suggest that APC would improve cerebral vasospasm following subarachnoid hemorrhage, possibly by decreasing the amount of subarachnoid clot and normalizing the impaired nitric oxide production/release.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0160-2446
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
39
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
729-38
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11973417-Animals,
pubmed-meshheading:11973417-Anticoagulants,
pubmed-meshheading:11973417-Basilar Artery,
pubmed-meshheading:11973417-Disease Models, Animal,
pubmed-meshheading:11973417-Male,
pubmed-meshheading:11973417-Protein C,
pubmed-meshheading:11973417-Rabbits,
pubmed-meshheading:11973417-Subarachnoid Hemorrhage,
pubmed-meshheading:11973417-Vasoconstriction,
pubmed-meshheading:11973417-Vasospasm, Intracranial
|
pubmed:year |
2002
|
pubmed:articleTitle |
Inhibitory effect of activated protein C on cerebral vasospasm after subarachnoid hemorrhage in the rabbit.
|
pubmed:affiliation |
Department of Neurosurgery, School of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|