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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017337,
umls-concept:C0040649,
umls-concept:C0205145,
umls-concept:C0205147,
umls-concept:C0205171,
umls-concept:C0213045,
umls-concept:C0243037,
umls-concept:C1334043,
umls-concept:C1335858,
umls-concept:C1413398,
umls-concept:C1861559,
umls-concept:C2587213,
umls-concept:C2697616
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pubmed:issue |
9
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pubmed:dateCreated |
2002-4-25
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pubmed:databankReference |
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pubmed:abstractText |
The cdc25C phosphatase participates in regulating transition from the G2 phase of the cell cycle to mitosis by dephosphorylating cyclin-dependent kinase 1. The tumor suppressor p53 down-regulates expression of cdc25C as part of G2/M checkpoint control. Transcription of cdc25C oscillates during the cell cycle with no expression in resting cells and maximum transcription in G2. We had identified earlier a new mechanism of cell cycle-dependent transcription that is regulated by a cell cycle-dependent element (CDE) in conjunction with a cell cycle genes homology region (CHR). The human cdc25C gene was the first example. CDE/CHR tandem elements have since been found in promoters of many cell cycle genes. Here we show that the mouse cdc25C gene is regulated by a CHR but does not hold a CDE. Therefore, it is the first identified gene with CHR-dependent transcriptional regulation during the cell cycle not relying on a CDE located upstream of it. The CHR leads to repression of cdc25C transcription early in the cell cycle and directs a release of this repression in G2. Furthermore, we find that this CHR can cooperate in cell cycle-dependent transcription with elements placed directly upstream of it binding E2F, Sp1 or Sp3 transcription factors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-10086339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-10454592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-10466809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-10521489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-10656985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-10760507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-11068036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-11071927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-11096075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-11104768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-11350945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-11396965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-11433027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-1310893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-1961714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-2195549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-2993923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-7479023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-7556094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-7592676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-7736585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-7828585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-8070411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-8276463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-8334989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-8413249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-8599118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-8657141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-8760872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-8806697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-9396796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-9426200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-9469818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-9584162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-9591776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-9627118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-9662327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-9679054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-9694791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972334-9891044
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Binding Factor,
http://linkedlifedata.com/resource/pubmed/chemical/CDC25C protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cdc25c protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E2F Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/SP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sp1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sp3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/cdc25 Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/nuclear factor Y
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1362-4962
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1967-76
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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