Source:http://linkedlifedata.com/resource/pubmed/id/11969245
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2002-4-23
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pubmed:abstractText |
The distribution of the calcium binding protein neurocalcin a has been examined in the enteric nervous system of young adult (3 months) and aged (24+ months) male rats by immunofluorescence. Neurocalcin-immunoreactive (NC-ir) neurons were observed in the submucous and myenteric plexuses throughout the gastrointestinal tract from the oesophagus to the distal large intestine. NC-ir nerve terminals were also seen on NC-ir and NC-negative neurons. Semiquantitative estimates revealed fewer NC-ir neurons in the submucous plexus than in the myenteric plexus. The greatest occurrence of NC-ir neurons was in the small and large intestine. NC-ir axons were seen in the mucosa and also in between the ganglia of the myenteric plexus. In the aged rats, there were no discernible changes in the numbers of NC-ir neurons in th e oesophagus and stomach, with an increase in the pylorus and slight decreases in the small and large intestines. No decrease in NC-ir was observed in the distal large intestine. NC-ir neurons never contained lipofuscin age pigment and many enteric neuro ns devoid of NC-ir contained age pigment. Like other previously investigated calcium-binding proteins in enteric neurons, the distribution of NC shows much variability from one part of the intestine to another. The observed slight decreases in the number of NC-ir enteric neurons in aged rats may compromise the regulation of calcium in these neurons.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcium-Sensing,
http://linkedlifedata.com/resource/pubmed/chemical/Vsnl1 protein, rat
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0143-4160
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2002 Elsevier Science Ltd. All rights reserved.
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11969245-Aging,
pubmed-meshheading:11969245-Animals,
pubmed-meshheading:11969245-Calcium-Binding Proteins,
pubmed-meshheading:11969245-Enteric Nervous System,
pubmed-meshheading:11969245-Esophagus,
pubmed-meshheading:11969245-Intestine, Large,
pubmed-meshheading:11969245-Intestine, Small,
pubmed-meshheading:11969245-Nerve Tissue Proteins,
pubmed-meshheading:11969245-Neurocalcin,
pubmed-meshheading:11969245-Rats,
pubmed-meshheading:11969245-Rats, Wistar,
pubmed-meshheading:11969245-Receptors, Calcium-Sensing,
pubmed-meshheading:11969245-Stomach,
pubmed-meshheading:11969245-Tissue Distribution
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pubmed:year |
2002
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pubmed:articleTitle |
Neurocalcin-alpha immunoreactivity in the enteric nervous system of young and aged rats.
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pubmed:affiliation |
School of Biosciences, University of Wales Cardiff, Cardiff, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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