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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-4-19
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pubmed:abstractText |
We have identified four major genes or quantitative trait loci (QTLs) that determine duration of loss of righting reflex (LORR), induced by sedative doses of ethanol: Lore1, Lore2, Lore4, and Lore5. Together these genes explain more than 50% of the phenotypic variance for sensitivity to the sedative/hypnotic effects of ethanol between the Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) strains of mice. The derivation of these strains is reviewed here.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0145-6008
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
149-57
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11964553-Animals,
pubmed-meshheading:11964553-Crosses, Genetic,
pubmed-meshheading:11964553-Ethanol,
pubmed-meshheading:11964553-Heterozygote,
pubmed-meshheading:11964553-Homozygote,
pubmed-meshheading:11964553-Hypnotics and Sedatives,
pubmed-meshheading:11964553-Mice,
pubmed-meshheading:11964553-Mice, Congenic,
pubmed-meshheading:11964553-Mice, Inbred AKR,
pubmed-meshheading:11964553-Mice, Inbred BALB C,
pubmed-meshheading:11964553-Mice, Inbred C3H,
pubmed-meshheading:11964553-Mice, Inbred C57BL,
pubmed-meshheading:11964553-Mice, Inbred DBA,
pubmed-meshheading:11964553-Phenotype,
pubmed-meshheading:11964553-Quantitative Trait, Heritable
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pubmed:year |
2002
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pubmed:articleTitle |
Reciprocal congenics defining individual quantitative trait Loci for sedative/hypnotic sensitivity to ethanol.
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pubmed:affiliation |
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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