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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0015576,
umls-concept:C0017262,
umls-concept:C0018330,
umls-concept:C0028630,
umls-concept:C0035253,
umls-concept:C0086418,
umls-concept:C0332281,
umls-concept:C0439662,
umls-concept:C0680022,
umls-concept:C1171362,
umls-concept:C1515670
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pubmed:issue |
9
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pubmed:dateCreated |
2002-4-19
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pubmed:abstractText |
TAL-1 is a basic helix-loop-helix oncoprotein that is expressed in up to 30% of T-cell acute lymphoblastic leukemias but not in the T lineage. We have cloned a complementary DNA, called Human Immune Associated Nucleotide 1 (hIAN1), whose messenger RNA (mRNA) level expression is inversely correlated to the TAL-1 mRNA level in human leukemic T-cell lines. The hIAN1 encodes a 38-kd protein that belongs to a novel family of proteins conserved from plants to humans and characterized by motifs related to, but highly divergent from, the consensus motifs found in guanosine triphosphate (GTP)-binding proteins. Despite these divergent amino acids at positions involved in GTP/guanosine diphosphate (GDP) binding and guanosine triphosphatase (GTPase) activities, we found that hIAN1 specifically binds GDP (K(d) = 0.47 microM) and GTP (K(d) = 6 microM) and exhibits intrinsic GTPase activity. Among mature hematopoietic cells, hIAN1 is specifically expressed in resting T and B lymphocytes, and its expression level tremendously decreased at the protein but not the mRNA level during B- or T-lymphocyte activation, suggesting a specific role for this new type of GTPase during the immune response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/TAL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tal1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3293-301
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pubmed:dateRevised |
2007-5-17
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pubmed:meshHeading |
pubmed-meshheading:11964296-Amino Acid Sequence,
pubmed-meshheading:11964296-B-Lymphocytes,
pubmed-meshheading:11964296-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:11964296-Chromosomes, Human, Pair 7,
pubmed-meshheading:11964296-DNA-Binding Proteins,
pubmed-meshheading:11964296-GTP Phosphohydrolases,
pubmed-meshheading:11964296-GTP-Binding Proteins,
pubmed-meshheading:11964296-Guanosine Diphosphate,
pubmed-meshheading:11964296-Guanosine Triphosphate,
pubmed-meshheading:11964296-Humans,
pubmed-meshheading:11964296-Jurkat Cells,
pubmed-meshheading:11964296-Lymphocyte Activation,
pubmed-meshheading:11964296-Molecular Sequence Data,
pubmed-meshheading:11964296-Protein Binding,
pubmed-meshheading:11964296-Proto-Oncogene Proteins,
pubmed-meshheading:11964296-RNA, Messenger,
pubmed-meshheading:11964296-Sequence Alignment,
pubmed-meshheading:11964296-T-Lymphocytes,
pubmed-meshheading:11964296-Transcription Factors,
pubmed-meshheading:11964296-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells.
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pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale U474, ICGM, Maternité Port-Royal, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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