Linked Life Data

11962692

Source:http://linkedlifedata.com/resource/pubmed/id/11962692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-4-18
pubmed:abstractText
To evaluate the mutagenicity of 1-carboxyl-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone (HXCA), which is an impurity present in Food Red No. 104 (FR104, Phloxine B, the Japanese counterpart of D&C Red No. 28), HXCA was isolatedfrom FR104 using pH-zone-refining counter-current chromatography and preparative HPLC. A large amount of HXCA was synthesized to perform the Ames test, and its identity was confirmed by comparison of its HPLC retention time, UV-Vis, MS and NMR spectra with those of HXCA isolated from FR104. The results of the Ames test using synthetic HXCA showed that it did not possess mutagenic activity. The results of the mutagenicity test for HXCA will provide useful information for the establishment of an upper limit for HXCA in FR104 (or D&C Red No. 28) for use in regulatory considerations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0265-203X
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
350-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Lack of mutagenicity of a red food colour impurity (1-carboxyl-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone) in phloxine B.
pubmed:affiliation
San-Ei Gen F. F. I., Inc., Toyonaka, Osaka, Japan. haoki@saneigenffi.co.jp
pubmed:publicationType
Journal Article