11960784

Source:http://linkedlifedata.com/resource/pubmed/id/11960784

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021853, umls-concept:C0036751, umls-concept:C0205245, umls-concept:C0206745, umls-concept:C0289174, umls-concept:C0450429, umls-concept:C0936012
pubmed:issue	5
pubmed:dateCreated	2002-4-18
pubmed:abstractText	The distribution and function of the 5-hydroxytryptamine (5-HT(2A)) receptor were investigated in the intestines of wild-type (5-HT(2A) +/+) and knockout (5-HT(2A) -/-) mice. In 5-HT(2A) +/+ mice, rats, and guinea pigs, 5-HT(2A) receptor immunoreactivity was found on circular and longitudinal smooth muscle cells, neurons, enterocytes, and Paneth cells. Muscular 5-HT(2A) receptors were concentrated in caveolae; neuronal 5-HT(2A) receptors were found intracellularly and on the plasma membranes of nerve cell bodies and axons. Neuronal 5-HT(2A) immunoreactivity was detected as early as E14 in ganglia, intravillus nerves, and the deep muscle plexus. The 5-HT(2A) -/- colon did not express 5-HT(2A) receptors and did not contract in response to exogenous 5-HT. 5-HT(2A) -/- enterocytes were smaller, Paneth cells fewer, and muscle layers thinner (and showed degeneration) compared with those of 5-HT(2A) +/+ littermates. The 5-HT(2A) receptor may thus be required for the maintenance and/or development of enteric neuroeffectors and other enteric functions, although gastrointestinal and colonic transit times in 5-HT(2A) -/- and +/+ mice did not differ significantly.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA-13696, http://linkedlifedata.com/resource/pubmed/grant/HD-35632, http://linkedlifedata.com/resource/pubmed/grant/NS-12969, http://linkedlifedata.com/resource/pubmed/grant/NS-15547, http://linkedlifedata.com/resource/pubmed/grant/RR-10506
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100901227
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0193-1857
pubmed:author	pubmed-author:Fiorica-HowellsElenaE, pubmed-author:GershonMichael DMD, pubmed-author:GingrichJayJ, pubmed-author:HenReneR, pubmed-author:LiZhishanZ
pubmed:issnType	Print
pubmed:volume	282
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	G877-93
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:11960784-Animals, pubmed-meshheading:11960784-Enterocytes, pubmed-meshheading:11960784-Female, pubmed-meshheading:11960784-Fetus, pubmed-meshheading:11960784-Gastric Emptying, pubmed-meshheading:11960784-Gastrointestinal Motility, pubmed-meshheading:11960784-Immunohistochemistry, pubmed-meshheading:11960784-Intestines, pubmed-meshheading:11960784-Mice, pubmed-meshheading:11960784-Mice, Inbred C57BL, pubmed-meshheading:11960784-Mice, Knockout, pubmed-meshheading:11960784-Microscopy, Immunoelectron, pubmed-meshheading:11960784-Muscle, Smooth, pubmed-meshheading:11960784-Myenteric Plexus, pubmed-meshheading:11960784-Paneth Cells, pubmed-meshheading:11960784-Rats, pubmed-meshheading:11960784-Rats, Sprague-Dawley, pubmed-meshheading:11960784-Receptor, Serotonin, 5-HT2A, pubmed-meshheading:11960784-Receptors, Serotonin
pubmed:year	2002
pubmed:articleTitle	5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice.
pubmed:affiliation	Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA. ef7@columbia.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S.