Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-4-17
pubmed:abstractText
Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor transcription factor that regulates adipocyte differentiation and glucose homeostasis. PPARgamma agonists are potent therapeutic agents for the treatment of type 2 diabetes and obesity. PPARgamma agonists also prevent inflammation in animal models, suggesting their use for the treatment of human inflammatory diseases. Experimental allergic encephalomyelitis (EAE) is a Th1 cell-mediated inflammatory demyelinating disease model of multiple sclerosis (MS) and IL-12 plays a crucial role in the pathogenesis of EAE and MS. In this study we have examined the effect of PPARgamma agonists on the pathogenesis of EAE. In vivo treatment of SJL/J mice with PPARgamma agonists, 15-deoxydelta(12,14) prostaglandin J2 or Ciglitazone, decreased the duration and clinical severity of active immunization and adoptive transfer models of EAE. PPARgamma agonists inhibited EAE in association with a decrease in IL-12 production and differentiation of neural antigen-specific Th1 cells. In vitro treatment of activated T cells with PPARgamma agonists inhibited IL-12-induced activation of JAK-STAT signaling pathway and Th1 differentiation. These findings highlight the fact that PPARgamma agonists regulate central nervous system inflammation and demyelination by inhibiting IL-12 production, IL-12 signaling and Th1 differentiation in EAE.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/15-deoxy-delta(12,14)-prostaglandin..., http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Immunologic Factors, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12, http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2, http://linkedlifedata.com/resource/pubmed/chemical/Myelin Basic Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin D2, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear, http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles, http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/ciglitazone
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1466-4879
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-70
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11960303-Animals, pubmed-meshheading:11960303-Cell Differentiation, pubmed-meshheading:11960303-Cells, Cultured, pubmed-meshheading:11960303-DNA-Binding Proteins, pubmed-meshheading:11960303-Dose-Response Relationship, Drug, pubmed-meshheading:11960303-Encephalomyelitis, Autoimmune, Experimental, pubmed-meshheading:11960303-Immunologic Factors, pubmed-meshheading:11960303-Interleukin-12, pubmed-meshheading:11960303-Janus Kinase 2, pubmed-meshheading:11960303-Kinetics, pubmed-meshheading:11960303-Lymphocyte Activation, pubmed-meshheading:11960303-Macrophages, pubmed-meshheading:11960303-Mice, pubmed-meshheading:11960303-Microglia, pubmed-meshheading:11960303-Myelin Basic Proteins, pubmed-meshheading:11960303-Prostaglandin D2, pubmed-meshheading:11960303-Protein-Tyrosine Kinases, pubmed-meshheading:11960303-Proto-Oncogene Proteins, pubmed-meshheading:11960303-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:11960303-Signal Transduction, pubmed-meshheading:11960303-Spinal Cord, pubmed-meshheading:11960303-Th1 Cells, pubmed-meshheading:11960303-Thiazoles, pubmed-meshheading:11960303-Thiazolidinediones, pubmed-meshheading:11960303-Transcription Factors
pubmed:year
2002
pubmed:articleTitle
Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation.
pubmed:affiliation
Division of Neuroimmunology, Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't