rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0014072,
umls-concept:C0037083,
umls-concept:C0123759,
umls-concept:C0243192,
umls-concept:C0332206,
umls-concept:C1335238,
umls-concept:C1423842,
umls-concept:C1511938,
umls-concept:C1710082,
umls-concept:C1819439
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pubmed:issue |
2
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pubmed:dateCreated |
2002-4-17
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pubmed:abstractText |
Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor transcription factor that regulates adipocyte differentiation and glucose homeostasis. PPARgamma agonists are potent therapeutic agents for the treatment of type 2 diabetes and obesity. PPARgamma agonists also prevent inflammation in animal models, suggesting their use for the treatment of human inflammatory diseases. Experimental allergic encephalomyelitis (EAE) is a Th1 cell-mediated inflammatory demyelinating disease model of multiple sclerosis (MS) and IL-12 plays a crucial role in the pathogenesis of EAE and MS. In this study we have examined the effect of PPARgamma agonists on the pathogenesis of EAE. In vivo treatment of SJL/J mice with PPARgamma agonists, 15-deoxydelta(12,14) prostaglandin J2 or Ciglitazone, decreased the duration and clinical severity of active immunization and adoptive transfer models of EAE. PPARgamma agonists inhibited EAE in association with a decrease in IL-12 production and differentiation of neural antigen-specific Th1 cells. In vitro treatment of activated T cells with PPARgamma agonists inhibited IL-12-induced activation of JAK-STAT signaling pathway and Th1 differentiation. These findings highlight the fact that PPARgamma agonists regulate central nervous system inflammation and demyelination by inhibiting IL-12 production, IL-12 signaling and Th1 differentiation in EAE.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-deoxy-delta(12,14)-prostaglandin...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunologic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Basic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin D2,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/ciglitazone
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1466-4879
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-70
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11960303-Animals,
pubmed-meshheading:11960303-Cell Differentiation,
pubmed-meshheading:11960303-Cells, Cultured,
pubmed-meshheading:11960303-DNA-Binding Proteins,
pubmed-meshheading:11960303-Dose-Response Relationship, Drug,
pubmed-meshheading:11960303-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:11960303-Immunologic Factors,
pubmed-meshheading:11960303-Interleukin-12,
pubmed-meshheading:11960303-Janus Kinase 2,
pubmed-meshheading:11960303-Kinetics,
pubmed-meshheading:11960303-Lymphocyte Activation,
pubmed-meshheading:11960303-Macrophages,
pubmed-meshheading:11960303-Mice,
pubmed-meshheading:11960303-Microglia,
pubmed-meshheading:11960303-Myelin Basic Proteins,
pubmed-meshheading:11960303-Prostaglandin D2,
pubmed-meshheading:11960303-Protein-Tyrosine Kinases,
pubmed-meshheading:11960303-Proto-Oncogene Proteins,
pubmed-meshheading:11960303-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:11960303-Signal Transduction,
pubmed-meshheading:11960303-Spinal Cord,
pubmed-meshheading:11960303-Th1 Cells,
pubmed-meshheading:11960303-Thiazoles,
pubmed-meshheading:11960303-Thiazolidinediones,
pubmed-meshheading:11960303-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation.
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pubmed:affiliation |
Division of Neuroimmunology, Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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