|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0019588,
umls-concept:C0020792,
umls-concept:C0205314,
umls-concept:C0205531,
umls-concept:C0226896,
umls-concept:C0231491,
umls-concept:C0442027,
umls-concept:C0597357,
umls-concept:C0679622,
umls-concept:C0935763,
umls-concept:C1527178,
umls-concept:C1527415,
umls-concept:C1705542,
umls-concept:C1705938
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2002-4-17
|
|
pubmed:abstractText |
A novel series of histamine H(3) receptor antagonists, based on the 4-benzyl-(1H-imidazole-4-yl) template, incorporating urea and carbamate linkers has been prepared. Compound 3j is a selective H(3) antagonist and demonstrates excellent oral plasma levels in the rat and monkey.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:AlbaneseMargaret MMM,
pubmed-author:AslanianRobertR,
pubmed-author:BerlinMichael YMY,
pubmed-author:BryantMatthewM,
pubmed-author:HeyJohn AJA,
pubmed-author:JiangYuehengY,
pubmed-author:McCormickKevin DKD,
pubmed-author:MutahiMwangi WMW,
pubmed-author:PiwinskiJohn JJJ,
pubmed-author:RosenblumStuart BSB,
pubmed-author:SheSusanS,
pubmed-author:ShihNeng YangNY,
pubmed-author:TingPauline CPC,
pubmed-author:WestRobertR,
pubmed-author:WilliamsShirley MSM,
pubmed-author:WongShing ChunSC,
pubmed-author:ZhuXiaohongX
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
25
|
|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
937-41
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:11958998-Administration, Oral,
pubmed-meshheading:11958998-Animals,
pubmed-meshheading:11958998-Biological Availability,
pubmed-meshheading:11958998-Haplorhini,
pubmed-meshheading:11958998-Histamine Antagonists,
pubmed-meshheading:11958998-Imidazoles,
pubmed-meshheading:11958998-Protein Binding,
pubmed-meshheading:11958998-Rats,
pubmed-meshheading:11958998-Receptors, Histamine H3,
pubmed-meshheading:11958998-Structure-Activity Relationship
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template.
|
|
pubmed:affiliation |
The Schering Plough Research Institute, Kenilworth, NJ 07033, USA. aslanian@spcorp.com
|
|
pubmed:publicationType |
Journal Article
|
