| pubmed-article:11957146 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11957146 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:11957146 | lifeskim:mentions | umls-concept:C0476089 | lld:lifeskim |
| pubmed-article:11957146 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:11957146 | lifeskim:mentions | umls-concept:C1332803 | lld:lifeskim |
| pubmed-article:11957146 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11957146 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11957146 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11957146 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11957146 | pubmed:dateCreated | 2002-4-16 | lld:pubmed |
| pubmed-article:11957146 | pubmed:abstractText | Mutations in the beta-catenin gene (CTNNB 1) with abnormal nuclear accumulation of beta-catenin have recently been identified in endometrial carcinoma (EC). Their relationship with microsatellite instability (MI) is unclear. It has been suggested that matrix metalloproteinase-7 (MMP-7) and cyclin D1 (cD) genes are targets for beta-catenin activation. DNA from 73 patients with EC was obtained from tumor and normal tissue (59 endometrioid and 14 nonendometrioid). CTNNB 1 mutations in exon 3 were assessed by single-strand conformation polymorphism and DNA sequencing. The results were correlated with immunostaining for beta-catenin, MMP-7, and cD. Three (CA)n repeats and mononucleotide tracts BAT 25 and BAT 26 had been previously used for MI analysis. CTNNB1 mutations were identified in 15 ECs (20.5%), all of them endometrioid carcinomas (15 of 59; 25.4%). They occurred in 6 of 19 MI-positive ECs (31.5%) and in 9 of 54 MI-negative ECs (16.6%). Eleven of the 15 CTNNB 1-mutated ECs showed beta-catenin nuclear immunostaining (P <.05). MMP-7 expression (>50% cells) was observed in 23 ECs, with 7 of these showing CTNNB 1 mutations. Significant expression of cD (>50% cells) was detected in 8 ECs, with 5 of these exhibiting CTNNB 1 mutations (P <.05). The results confirm that beta-catenin plays a role in endometrial carcinogenesis, particularly in endometrioid carcinomas. The results also suggest that MMP-7 and particularly cD may be targets of beta-catenin activation in ECs. | lld:pubmed |
| pubmed-article:11957146 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11957146 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11957146 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11957146 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11957146 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11957146 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11957146 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11957146 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11957146 | pubmed:issn | 0046-8177 | lld:pubmed |
| pubmed-article:11957146 | pubmed:author | pubmed-author:PratJaimeJ | lld:pubmed |
| pubmed-article:11957146 | pubmed:author | pubmed-author:Matias-GuiuXa... | lld:pubmed |
| pubmed-article:11957146 | pubmed:author | pubmed-author:MachinPilarP | lld:pubmed |
| pubmed-article:11957146 | pubmed:author | pubmed-author:CatasusLluisL | lld:pubmed |
| pubmed-article:11957146 | pubmed:author | pubmed-author:PonsCristinaC | lld:pubmed |
| pubmed-article:11957146 | pubmed:author | pubmed-author:MuñozJosefina... | lld:pubmed |
| pubmed-article:11957146 | pubmed:copyrightInfo | Copyright 2002, Elsevier Science (USA). All rights reserved. | lld:pubmed |
| pubmed-article:11957146 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11957146 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:11957146 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11957146 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11957146 | pubmed:pagination | 206-12 | lld:pubmed |
| pubmed-article:11957146 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11957146 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11957146 | pubmed:articleTitle | CTNNB1 mutations and beta-catenin expression in endometrial carcinomas. | lld:pubmed |
| pubmed-article:11957146 | pubmed:affiliation | Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. | lld:pubmed |
| pubmed-article:11957146 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11957146 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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