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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
|
pubmed:dateCreated |
1976-2-9
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pubmed:abstractText |
In order to determine the influence of a 6alpha-methyl group activity, the 6alpha-methyl derivative of digitoxigenin 3-acetate 14 was prepared and pharmacologically tested in comparison with digitoxigenen 3-acetate. The synthesis of 6alpha-methyldigitoxigenin 3-acetate (14) was performed starting from 21-hydroxy-4-pregnene-3,20-dione (1). According to the cardiac activity determined on guinea-pig isolated heart and by slow infusion in the cat, the 6alpha-methyldigitoxigenin 3-acetate (14) is not more active than digitoxigenin 3-acetate.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
18
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1258-61
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1195280-Animals,
pubmed-meshheading:1195280-Cardanolides,
pubmed-meshheading:1195280-Cats,
pubmed-meshheading:1195280-Digitoxigenin,
pubmed-meshheading:1195280-Guinea Pigs,
pubmed-meshheading:1195280-Molecular Conformation,
pubmed-meshheading:1195280-Myocardial Contraction,
pubmed-meshheading:1195280-Stimulation, Chemical
|
pubmed:year |
1975
|
pubmed:articleTitle |
Synthesis of 6alpha-methyldigitoxigenin 3-acetate.
|
pubmed:publicationType |
Journal Article,
In Vitro
|